Tet2/3 deletion

Intervention1 paper2 findings

Outcomes

Lymphoid expansion

upin mice1

1 study

Tet2/3 deletion induces lymphoid expansion in mice.
Animalsinvariant natural killer T cell
TET enzyme deficiency drives the selection of specific aneuploid cells in mice · bioRxiv · 1 Oct 2026 · Preprint

Genomic instability

upin mice1

1 study

Tet2/3 deletion is associated with genomic instability in mice.
Animalsfollowing transplantation into recipient miceinvariant natural killer T cell
TET enzyme deficiency drives the selection of specific aneuploid cells in mice · bioRxiv · 1 Oct 2026 · Preprint

AnimalsPreprint5 h

Loss of DNA methylation regulators accelerates clonal expansion by enriching rare pre-existing chromosomal gains such as chromosome 17 trisomy.

bioRxiv · López-Moyado IF et al.