After 12 months, estimated heart age relative to actual age fell 0.73 years with semaglutide, versus no significant change after weight-loss surgery.After 12 months, estimated heart age relative to actual age fell 0.73 years with semaglutide, versus no significant change after weight-loss surgery.
An atlas of gene activity covered 5.3 million cells from 55 rhesus macaques aged 0.5–21 years, revealing changes that varied by brain region and cell type.An atlas of gene activity covered 5.3 million cells from 55 rhesus macaques aged 0.5–21 years, revealing changes that varied by brain region and cell type.
Experiments in young and aged mice lacking a protein-cutting enzyme found less organ aging despite persistent signs of immune aging.Experiments in young and aged mice lacking a protein-cutting enzyme found less organ aging despite persistent signs of immune aging. Mice without the enzyme still showed major features of immune aging, including impaired function…
A 24-protein signature separated 10 younger from 10 older women; higher signature scores were linked to poorer combined grip strength and walking speed.A 24-protein signature separated 10 younger from 10 older women; higher signature scores were linked to poorer combined grip strength and walking speed.
Experiments in human natural killer cells linked age-related fat buildup to altered cell mechanics and weaker killing of target cells.Experiments in human natural killer cells linked age-related fat buildup to altered cell mechanics and weaker killing of target cells. Their membranes were more fluid, and the supporting layer beneath the membrane was less stiff.
In a randomized trial, 600 hospitalized adults with swallowing difficulties received one of two care programs; most differences were no longer evident at six months.In a randomized trial, 600 hospitalized adults with swallowing difficulties received one of two care programs; most differences were no longer evident at six months.
Accepted, not yet published: randomized trial · 600 peopleInterventions
Who was studied600 hospitalized older adults with oropharyngeal dysphagia, six months
What changedQuality of life was better with enhanced swallowing care than with the minimal program at one month
The catchRecovery after hospitalization could explain improvements shared by both care programs
Female mice with a muscle-specific gene deletion retained strength and had an 11% longer median lifespan than female controls.Female mice with a muscle-specific gene deletion retained strength and had an 11% longer median lifespan than female controls. Terf2 encodes TRF2, a protein that protects chromosome ends.
Later cancer-promoting mutations were linked to growth advantages up to 100-fold larger than those of early mutations in blood cell families.Later cancer-promoting mutations were linked to growth advantages up to 100-fold larger than those of early mutations in blood cell families.
Among adults with normal standard-range hearing, average very high-frequency thresholds ranged from −12.5 to 97.5 decibels of hearing level.Among adults with normal standard-range hearing, average very high-frequency thresholds ranged from −12.5 to 97.5 decibels of hearing level.
Walking speed was 0.14 meters per second higher than with home exercise alone after 12 weeks in a randomized trial.Walking speed was 0.14 meters per second higher than with home exercise alone after 12 weeks in a randomized trial. In Guangzhou, China, 51 adults aged 60 or older living at home with at least one chronic disease completed a…
After six months of oral exposure in male mice, their first-generation offspring developed aging-like tissue changes and had shorter lifespans.After six months of oral exposure in male mice, their first-generation offspring developed aging-like tissue changes and had shorter lifespans.
Over 36 months, 46.1% of older hospital patients in the lowest phase-angle group died, compared with 25.1% in the highest group.Over 36 months, 46.1% of older hospital patients in the lowest phase-angle group died, compared with 25.1% in the highest group. The 538 hospitalized older adults in this prospective multicenter study averaged 81.2 years of age…
An observational study of 208 Cuban adults aged 20–104 linked an immune cell marker to age, poorer physical function and cognitive decline.An observational study of 208 Cuban adults aged 20–104 linked an immune cell marker to age, poorer physical function and cognitive decline.
A laboratory experiment used sperm collected from male fish at three ages to assess reproduction, finding no trade-off between early reproductive success and lifespan.A laboratory experiment used sperm collected from male fish at three ages to assess reproduction, finding no trade-off between early reproductive success and lifespan.
A commentary on macaque brain studies describes context-dependent molecular aging and links to Alzheimer’s disease.A commentary on macaque brain studies describes context-dependent molecular aging and links to Alzheimer’s disease. Macaque brains were the focus of a commentary on research mapping aging across cell types, brain regions and…
At 26 weeks, lean mass fell 6.6% with semaglutide plus placebo; adding 200 mg trevogrumab reduced that decline by 3.1 percentage points.At 26 weeks, lean mass fell 6.6% with semaglutide plus placebo; adding 200 mg trevogrumab reduced that decline by 3.1 percentage points. Adults aged 18–80 with obesity joined a two-part, phase 2, double-blind, placebo-controlled…
Five weeks after receiving T cells from young or old donors, older mice had stiffer arteries regardless of the cells’ age.Five weeks after receiving T cells from young or old donors, older mice had stiffer arteries regardless of the cells’ age. Young and old mice genetically lacking T and B cells, two types of immune cell, received T cells from young…
A cohort analysis of 1,895 people taking HIV-suppressing drugs linked viral reservoir measurements to biological aging scores and several diseases.A cohort analysis of 1,895 people taking HIV-suppressing drugs linked viral reservoir measurements to biological aging scores and several diseases.
Relative risks with sustained increases versus persistently lower activity were 0.776 in the US, 0.764 in Europe and 0.725 in South Korea; below 1 means lower risk.Relative risks with sustained increases versus persistently lower activity were 0.776 in the US, 0.764 in Europe and 0.725 in South Korea; below 1 means lower risk.
In the 12-week trial, estimated differences in score trends versus controls were 0.39 for thinking and minus 1.28 for loneliness, favoring walking.In the 12-week trial, estimated differences in score trends versus controls were 0.39 for thinking and minus 1.28 for loneliness, favoring walking.
Among 14,139 people, 44 blood proteins were linked to future stroke risk, with 26 associations replicated in two independent groups.Among 14,139 people, 44 blood proteins were linked to future stroke risk, with 26 associations replicated in two independent groups. Among 14,139 people without a previous stroke, researchers combined results from two cohort…
Blocking a hormone receptor for one week restored heat production in mice aged 70–75 weeks, as experiments traced immune control of brown fat.Blocking a hormone receptor for one week restored heat production in mice aged 70–75 weeks, as experiments traced immune control of brown fat.
With 100 representing expected mortality based on Finns without diabetes, death ratios were 288 for diagnosis by 40 and 56 at 80 or older.With 100 representing expected mortality based on Finns without diabetes, death ratios were 288 for diagnosis by 40 and 56 at 80 or older. In Finland, 485,713 people with type 2 diabetes were included in a retrospective dynamic…
Each additional year of age was associated with 4.57 picograms per milliliter less resting plasma irisin, after accounting for body composition and physical activity.Each additional year of age was associated with 4.57 picograms per milliliter less resting plasma irisin, after accounting for body composition and physical activity.
At day 90, a lung gas-transfer measure rose by a median 1.36 mL/min/mmHg with fisetin versus 0.13 with placebo.At day 90, a lung gas-transfer measure rose by a median 1.36 mL/min/mmHg with fisetin versus 0.13 with placebo. Ten adults with common variable immunodeficiency, an immune disorder, and granulomatous-lymphocytic interstitial lung…
For weight-lowering interventions, median lifespan gains over controls rose from 6.2% in the lightest quarter of males to 20.2% in the heaviest.For weight-lowering interventions, median lifespan gains over controls rose from 6.2% in the lightest quarter of males to 20.2% in the heaviest.
Who was studied33,780 mice allowed to eat freely, against male mice in lightest weight quartile
What changedWith weight-lowering interventions, male mice's median lifespan gains over controls rose from 6.2% in the lightest quarter to 20.2% in the heaviest
The catchPoor control health could inflate apparent lifespan benefits in heavier mice
Nonfatal heart attacks and strokes plus cardiovascular deaths totaled 683 with oral semaglutide versus 791 with placebo over a median 49.5 months.Nonfatal heart attacks and strokes plus cardiovascular deaths totaled 683 with oral semaglutide versus 791 with placebo over a median 49.5 months.
Some immune cells in the small intestine showed metabolic changes with aging, while those in the colon were relatively resistant to fat buildup.Some immune cells in the small intestine showed metabolic changes with aging, while those in the colon were relatively resistant to fat buildup. These cells help regulate the gut’s nerve and muscle function.
Models estimated 2.7–3.1 overdiagnoses per prostate cancer death prevented at 72 versus 4.5–5.1 at 76 in men without other illnesses.Models estimated 2.7–3.1 overdiagnoses per prostate cancer death prevented at 72 versus 4.5–5.1 at 76 in men without other illnesses. Men screened every two years from ages 50 to 70, with no prostate cancer diagnosis by 72, were…
The genetic comparison identified 114 rare protein-coding variants enriched in superagers compared with average-cognition controls and a population reference database.The genetic comparison identified 114 rare protein-coding variants enriched in superagers compared with average-cognition controls and a population reference database.
Preprint: genetic association · 136 peoplePopulations
Who was studied136 cognitive superagers
What changed114 rare protein-coding variants were more common in superagers than in controls and population reference data
The catchStandard single-variant and burden analyses found no loci meeting the exome-wide statistical threshold
In cell-culture experiments, SenLect labeled senescent cells and enriched them by selectively eliminating neighboring cells that were still dividing.In cell-culture experiments, SenLect labeled senescent cells and enriched them by selectively eliminating neighboring cells that were still dividing. Senescence is a state in which cells stop dividing.
