Mitochondrion
Cell component48 papersMeSH D008928GO 0005739
- Human trial2
- Humans2
- Animals23
- Model organisms6
- Cells5
- In silico1
Latest
48The effects of chronic beetroot juice supplementation with resistance training on skeletal muscle mitochondrial and redox markers in middle-aged and older adults
Darker skin is linked to fewer mtDNA variants from sun exposure
Photoexposed light skin possessed six-fold more variants than dark skin across paired biopsies from six older men.Photoexposed light skin possessed six-fold more variants than dark skin across paired biopsies from six older men.
Elamipretide improves oocyte quality and restores fertility in aged mice
The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway.The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway.
Rapamycin improves efferocytosis and reduces plaques in mice
In ApoE-/- mice, rapamycin reduced aortic lipid-positive area from 25.32 ± 0.98% to 12.28 ± 1.49% and increased plaque efferocytosis index from 0.36 ±…In ApoE-/- mice, rapamycin reduced aortic lipid-positive area from 25.32 ± 0.98% to 12.28 ± 1.49% and increased plaque efferocytosis index from 0.36 ± 0.02 to 1.37 ± 0.15.
Voluntary running shows limited neuroprotection in mice
In 5xFAD mice, 16 weeks of voluntary wheel running altered fat tissue but produced modest hippocampal changes and failed to improve amyloid pathology…In 5xFAD mice, 16 weeks of voluntary wheel running altered fat tissue but produced modest hippocampal changes and failed to improve amyloid pathology or memory.
Melissic acid reduces senescence in human stem cells via cAMP signaling
A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular…A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.
Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies
Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged…Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.
Peroxisomal stress drives cellular senescence by relocating SCAF1 to mitochondria
Processed SCAF1 halts mitochondrial ribosome assembly and induces senescence in human cell models following peroxisome import stress.Processed SCAF1 halts mitochondrial ribosome assembly and induces senescence in human cell models following peroxisome import stress.
Proteomic and bioinformatic profiling of the aging mouse heart-diaphragm system
Human neurons accumulate far more mutations over lifespan than shorter-lived mammals
Cortical neurons gain mutations at similar yearly rates across six species, leaving aged humans with uniquely high mutational burdens and…Cortical neurons gain mutations at similar yearly rates across six species, leaving aged humans with uniquely high mutational burdens and transcriptomic dysregulation.
Empagliflozin Improves Angina and Endothelial Dysfunction Indices in Angina and No Obstructive Coronary Arteries (ANOCA)
Chemogenetic hydrogen sulfide production reverses vascular remodeling in aged mice
Targeting hydrogen sulfide generation to endothelial mitochondria mitigated senescence programs and reversed vascular remodeling in aged mice.Targeting hydrogen sulfide generation to endothelial mitochondria mitigated senescence programs and reversed vascular remodeling in aged mice.
Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice
Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and…Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance.
USP-48 modulates mitochondrial stress and enables longevity in low-insulin worms
A genome-wide screen in roundworms links histone H2B deubiquitination by USP-48 to mitochondrial stress signaling and extended lifespan.A genome-wide screen in roundworms links histone H2B deubiquitination by USP-48 to mitochondrial stress signaling and extended lifespan.
Mitohormesis linking metabolic dysfunction and neurodegeneration: implications for dementia and therapeutic strategies
A PPAR-gamma counterpart protects worm neurons by coordinating lipids and mitochondria
Researchers show that SEX-1 regulates sphingolipid metabolism and mitochondrial quality control in Caenorhabditis elegans, but its protective activity…Researchers show that SEX-1 regulates sphingolipid metabolism and mitochondrial quality control in Caenorhabditis elegans, but its protective activity declines with age.
4-Octyl itaconate restores parotid gland function in aging mice
The itaconate derivative reduces fibrosis and lipid buildup while curbing oxidative stress through AMPK signaling pathways.The itaconate derivative reduces fibrosis and lipid buildup while curbing oxidative stress through AMPK signaling pathways.
Alpha-synuclein impairs triglyceride metabolism and mitochondrial structure in aging nematodes
Restoring lipid balance through medium-chain triglycerides or fatty acid inhibition protected worms from alpha-synuclein-driven movement deficits.Restoring lipid balance through medium-chain triglycerides or fatty acid inhibition protected worms from alpha-synuclein-driven movement deficits.