SIRT1
Gene4 papers2 findingsHGNC 14929MGI 2135607NCBI Gene 23411Taxon 9606
- Animals2
Effects
2Mitochondrial dysfunction
downin reviews1
1 study
Mitochondrial dysfunction
downin reviews1
SIRT1 protects against mitochondrial dysfunction.
“SIRT1 maintains mitochondrial function through three interconnected pathways: PGC-1α-driven mitochondria biogenesis, FOXO-dependent antioxidant defense, and mitophagic clearance of damaged organelles.”
Review
SIRT1 in Senescence: Mitochondria and Immune Crosstalk · Biology · 8 Sep 2026
Cellular senescence
downin reviews1
1 study
Cellular senescence
downin reviews1
SIRT1 decreases cellular senescence.
“SIRT1 levels and activity fall with age, and this decline directly promotes senescence.”
Review
SIRT1 in Senescence: Mitochondria and Immune Crosstalk · Biology · 8 Sep 2026
Latest
4Reproductive Medicine and BiologyReview
Mitochondrial-Targeted Phytochemicals in Reproductive Aging: Mechanisms and Translational Potential
BiogerontologyAnimals
Erigeron breviscapus extends worm lifespan and reduces senescence markers in mice
The herbal extract activates AMPK-SIRT1 signaling, enhancing antioxidant defenses and modulating apoptosis to alleviate tissue aging across both model…The herbal extract activates AMPK-SIRT1 signaling, enhancing antioxidant defenses and modulating apoptosis to alleviate tissue aging across both model organisms.