BNIP3

1. Caloric restriction increases BNIP3 in rats.

   Animalsin old rats40% CRliver40%13 monthsmales

   Impact of aging and caloric restriction on markers of mitochondrial dynamics, biogenesis, mitophagy, and autophagy in multiple metabolically active tissues · Research Square · 4 Sep 2026 · Preprint

Caloric restriction →

1. BNIP3 is required for mitophagy in cells.

   “Mito-I effectively upregulates BCL2-interacting protein 3 (BNIP3), which acts as a mitophagy receptor and is indispensable for Mito-I-induced mitophagy.”

   CellsMito-I treatment

   MITOPHAGY ACTIVATION EXTENDS LONGEVITY AND PREVENTS AGE-RELATED CARDIAC FUNCTIONAL DECLINE · GSA 2024 abstract · 31 Dec 2024

Mitophagy →

1. HIF3A increases BNIP3 in mice.

   Animalsin senescent cardiomyocytes

   Mitochondrial Transplantation Rejuvenates Aging Heart by Restoring Mitophagy Flux via the HIF-3α-BNIP3 Axis · Aging cell · 23 Sep 2026

HIF3A →