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TodayMon 5 OctMonday 5 October18 papers

Journal of Orthopaedic TranslationAnimals

Low-intensity exercise eases age-related osteoarthritis in mice

In aged mice and cultured chondrocytes, swimming and a targeted PGC-1α-activating nanoparticle suppressed senescence and altered glycolysis to protect…In aged mice and cultured chondrocytes, swimming and a targeted PGC-1α-activating nanoparticle suppressed senescence and altered glycolysis to protect joints. In aged mice, low-intensity swimming exercise attenuated age-related osteoarthritis.

Graphical abstract
Exercise
Drug Design, Development and TherapyHumans

GLP-1 agonists linked to lower dementia risk after COVID-19

GLP-1 receptor agonist initiation was associated with a lower hazard of incident dementia than DPP-4 inhibitors (HR 0.64) in diabetic COVID-19…GLP-1 receptor agonist initiation was associated with a lower hazard of incident dementia than DPP-4 inhibitors (HR 0.64) in diabetic COVID-19 survivors. In a study of COVID-19 survivors aged 50 years and older with type 2 diabetes, researchers compared the outcomes of initiating…

Journal of Cachexia, Sarcopenia and MuscleAnimals

A 5:2 fasting regimen curbs muscle impairment in mice

Twelve cycles of a 5:2 intermittent fasting regimen improved grip strength and muscle cross-sectional area in mice fed a high-fat diet without…Twelve cycles of a 5:2 intermittent fasting regimen improved grip strength and muscle cross-sectional area in mice fed a high-fat diet without altering cumulative energy intake.

Dietary restriction
bioRxivAnimalsPreprint

Nicotinamide riboside improves parasite control in mice

In mice infected with Trypanosoma cruzi, treatment with the NAD+ precursor improved CD8+ T-cell function and reduced parasite burden in blood and…In mice infected with Trypanosoma cruzi, treatment with the NAD+ precursor improved CD8+ T-cell function and reduced parasite burden in blood and skeletal muscle. In mice infected with the parasite Trypanosoma cruzi, treatment with nicotinamide riboside improved immune control by…

Muscle

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Advanced ScienceCells

Light- and enzyme-gated prodrugs target senescent cells

Pairing 390 nm irradiation with beta-galactosidase cleavage improved prodrug selectivity in senescence models and increased death in senescent lung…Pairing 390 nm irradiation with beta-galactosidase cleavage improved prodrug selectivity in senescence models and increased death in senescent lung cancer patient-derived organoids.

Lung
Aging CellCells

Direct conversion to neural stem cells de-ages human blood cells

Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process.Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process. In human blood cells from donors ranging from neonatal to 101 years of age, researchers tracked cellular rejuvenation during direct lineage…

Epigenetic regulation of gene expression
Frontiers in PhysiologyHuman trial

Baguazhang lowers systolic blood pressure in postmenopausal women

In a randomized trial, 12 weeks of the mind-body exercise lowered systolic blood pressure by 7.2 mmHg compared with habitual lifestyle.In a randomized trial, 12 weeks of the mind-body exercise lowered systolic blood pressure by 7.2 mmHg compared with habitual lifestyle. Forty-six sedentary postmenopausal women enrolled in a 12-week randomized controlled trial evaluating Baguazhang, a traditional Chinese mind-body…

Figure 1
Exercise
Frontiers in ImmunologyAnimals

Fungus drives spleen aging in mice, eased by astragaloside IV

In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune…In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune function and iron homeostasis. In aged mice, exposure to the fungus Kazachstania pintolopesii accelerates splenic senescence, according to a study…

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Blood and immune system
Alzheimer's Research & TherapyHumans

Aspirin initiation before 65 links to lower Alzheimer's risk

Across electronic health records and insurance claims databases, starting aspirin before age 65 was consistently associated with lower incident…Across electronic health records and insurance claims databases, starting aspirin before age 65 was consistently associated with lower incident Alzheimer’s disease risk. In human health records and cortical organoids, researchers evaluated aspirin as a repurposed candidate against…

Figure 1
Alzheimer's disease
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