PPARGC1A
Gene7 papers2 findingsHGNC 9237MGI 1342774NCBI Gene 10891Taxon 9606
- Animals3
- Cells1
Interventions
2High-intensity interval training
upin mice1
1 study
High-intensity interval training
upin mice1
High-intensity interval training increases PPARGC1A in mice.
Animalsshort session (≤10 minute)10-minute HIIT regimen 3-days-a-week8 weeksfemales
Hallmarks of Aging Associate with High Intensity Interval Training Benefits and Frailty in Female C57Bl/6J Mice · The journals of gerontology. Series A, Biological sciences and medical sciences · 25 Sep 2026
Exercise
upin humans1
1 study
Exercise
upin humans1
Exercise activates PPARGC1A in humans.
“Exercise opposes this cascade through the AMPK-PGC-1α axis, which coordinately activates four mitochondrial quality control (MQC) modules: biogenesis, antioxidant defense, dynamics, and mitophagy.”
Reviewvia AMPK-PGC-1α axisrepeated training
Mitochondrial Quality Control Links Exercise to Sterile Inflammation in the Cardiovascular System: A Narrative Review · Antioxidants (Basel, Switzerland) · 7 Sep 2026
Latest
7Mitochondrial-Targeted Phytochemicals in Reproductive Aging: Mechanisms and Translational Potential
Senescent human astrocytes impair neuronal mitochondrial function through released factors
Conditioned medium from damaged astrocytes alters extracellular mitochondria and triggers ATP depletion and oxidative stress in human postmitotic…Conditioned medium from damaged astrocytes alters extracellular mitochondria and triggers ATP depletion and oxidative stress in human postmitotic neurons.
Hallmarks of Aging Associate with High Intensity Interval Training Benefits and Frailty in Female C57Bl/6J Mice
Inotodiol preserves muscle mass and function in aged mice
The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline.The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline.