DNA damage response
Pathway20 papers3 findingsGO 0006974
- Animals7
- Model organisms1
- Cells5
Upstream
1Telomere attrition
upin humans1
1 study
Telomere attrition
upin humans1
Telomere attrition activates DNA damage response in humans.
Reviewwhen telomeres become critically short with aging
Telomeres in Aging: Links to Clonal Hematopoiesis, Cardiovascular Disease, and Cancer · The American journal of medicine · 29 Sep 2026
Associations
2Immune cell
upin mice1
1 study
Immune cell
upin mice1
DNA damage response is associated with immune cell in mice.
Animalsin DDR-low vascular anchorsbrain
Brain cells organize into distinct DNA repair niches during mouse aging · bioRxiv : the preprint server for biology · 10 Sep 2026 · Preprint
Altered intercellular communication
upin mice1
1 study
Altered intercellular communication
upin mice1
DNA damage response is associated with altered intercellular communication in mice.
Animalsbrain
Brain cells organize into distinct DNA repair niches during mouse aging · bioRxiv : the preprint server for biology · 10 Sep 2026 · Preprint
Latest
29Brain cells organize into distinct DNA repair niches during mouse aging
Spatial transcriptomics shows neuronal and vascular DNA damage responses correspond to distinct local cell neighborhoods in aging brains.
bioRxiv : the preprint server for biology · Koshboresh A et al.
Pathogenic modulators of cellular senescence
Aging impairs blastema formation and tissue regeneration in Cladonema jellyfish
Older jellyfish medusae exhibit cell loss, heightened DNA damage, and defective wound closure that limit complex tentacle regrowth.
Aging cell · Kanehisa R et al.
Inhibiting CHK2 improves oocyte quality and reduces ovarian inflammation in aged mice
A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.
bioRxiv · Yang L et al.
Nucleoli buffer displaced heterochromatin to limit premature aging programs in cells
In cells expressing progerin, the nucleolus sequesters released lamina-associated domains to preserve gene repression and prevent worsening DNA damage.
bioRxiv · Mungo C et al.
Hybrid extracellular vesicles protect mouse skin from ultraviolet B photoaging
Vesicles fused from M2 macrophages and keratinocytes reduced oxidative stress, inflammation, and collagen degradation through the IL-4Rα/JAK/STAT3 pathway.
ACS applied materials & interfaces · Hao Y et al.
Base editing of the lamin farnesylation motif rescues progeria phenotypes in organoids
Lipid nanoparticle delivery of base-editing mRNA restored DNA repair and heterochromatin structure in human neuromuscular models of premature aging.
Nature communications · Kim DW et al.
Syringin reduces cellular senescence and pulmonary fibrosis in mice and cell models
Computational screening identified the natural compound, which interacts with CHK1 to blunt replication stress and fibrotic signaling.
Chinese journal of natural medicines · Wang Y et al.
Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis
Treating cells and an in vivo fibrosis model with a calcium chelator delayed senescence markers, reduced collagen buildup, and dampened inflammatory secretions.
Biochimica et biophysica acta. General subjects · Xu J et al.
Restoring HIRA chromatin maintenance improves aged mouse oocyte quality
Preventing HIRA SUMOylation rescues histone replacement, restoring chromatin integrity and developmental potential in aging mouse eggs.
bioRxiv · Hatanaka Y et al.