Stem cell differentiation
Pathway11 papers5 findingsGO 0048863
- Animals4
- Model organisms1
- Cells6
Interventions
2Micro- and nanoplastics
downin human cells1
1 study
Micro- and nanoplastics
downin human cells1
Micro- and nanoplastics impair stem cell differentiation in human cells.
Cellscortical organoids
Microplastics induce cellular senescence and alter network activity in human brain organoids · bioRxiv · 24 Sep 2026 · Preprint
Klotho-enriched extracellular vesicles
upin human cells1
1 study
Klotho-enriched extracellular vesicles
upin human cells1
Klotho-enriched extracellular vesicles increase stem cell differentiation in human cells.
“KL-EVs rescued the age-related differentiation bias of adult BMSCs by robustly prompting their osteogenic differentiation capacity.”
Cellsin vitro
Characterization of Umbilical Cord Mesenchymal Stromal Cells Overexpressing Klotho and In Vitro Anti-Aging Efficacy of Their Derived Extracellular Vesicles · International journal of molecular sciences · 19 Sep 2026
Upstream
3Myogenic progenitor cells
downin human cells1
1 study
Myogenic progenitor cells
downin human cells1
myogenic progenitor cells impair stem cell differentiation in human cells.
Cellsat 7d-recovery from disuse atrophyfemales
Altered cell communication impairs muscle recovery in older women after disuse · bioRxiv : the preprint server for biology · 24 Sep 2026 · Preprint
KL
upin human cells1
1 study
KL
upin human cells1
KL increases stem cell differentiation in human cells.
“genetic modification endowed UC-MSCs with prominent osteogenic differentiation potency and angiogenesis efficacy.”
Cellsin vitro
Characterization of Umbilical Cord Mesenchymal Stromal Cells Overexpressing Klotho and In Vitro Anti-Aging Efficacy of Their Derived Extracellular Vesicles · International journal of molecular sciences · 19 Sep 2026
miR-193b-3p
upin human cells1
1 study
miR-193b-3p
upin human cells1
miR-193b-3p improves stem cell differentiation in human cells.
CellssEV-mediated and synthetic
Extracellular vesicle microRNA promotes muscle regeneration by suppressing AP2M1 · Molecular therapy. Nucleic acids · 3 Sep 2026
Latest
11Neural stem cell exhaustion disrupts central nervous system renewal in aging colonial chordates
Researchers identified a conserved neural progenitor pool that drives weekly brain regeneration in Botryllus schlosseri but collapses during aging.Researchers identified a conserved neural progenitor pool that drives weekly brain regeneration in Botryllus schlosseri but collapses during aging.
Altered cell communication impairs muscle recovery in older women after disuse
Single-nucleus sequencing reveals disrupted signaling between satellite cells and fibro-adipogenic progenitors during muscle regrowth in older…Single-nucleus sequencing reveals disrupted signaling between satellite cells and fibro-adipogenic progenitors during muscle regrowth in older females.
Human lymph node fibroblasts show cellular aging features before rheumatoid arthritis onset
Fibroblasts from individuals at risk for rheumatoid arthritis exhibit impaired adipogenic differentiation and downregulated DNA repair and cell cycle…Fibroblasts from individuals at risk for rheumatoid arthritis exhibit impaired adipogenic differentiation and downregulated DNA repair and cell cycle pathways.
Extracellular vesicle microRNA promotes muscle regeneration by suppressing AP2M1
Delivering miR-193b-3p improved muscle repair in injured mice and targeted a protein elevated in sarcopenic human tissue.Delivering miR-193b-3p improved muscle repair in injured mice and targeted a protein elevated in sarcopenic human tissue.
Puerarin-loaded nanoparticles improve bone mass in mice
In ovariectomized mice, six weeks of treatment with pH-responsive puerarin nanoparticles restored trabecular bone architecture and increased bone…In ovariectomized mice, six weeks of treatment with pH-responsive puerarin nanoparticles restored trabecular bone architecture and increased bone mineral density.
Gender- and Age-Related Changes in the Spectrum of the Differentiation Potential of Individual Colonies of Stromal Precursors from Human Bone Marrow
Characterization of Umbilical Cord Mesenchymal Stromal Cells Overexpressing Klotho and In Vitro Anti-Aging Efficacy of Their Derived Extracellular Vesicles
Microplastics induce cellular senescence and alter network activity in human brain organoids
Exposure to diverse plastic particles triggered neuroinflammation, senescence-associated secretory phenotype pathways, and altered developmental…Exposure to diverse plastic particles triggered neuroinflammation, senescence-associated secretory phenotype pathways, and altered developmental trajectories in cortical organoid models.
Nuciferine reduces ovariectomy-induced bone loss in rats by activating autophagy
The lotus leaf alkaloid promoted bone formation and osteogenic differentiation in ovariectomized rats through the TFEB autophagy-lysosomal pathway.The lotus leaf alkaloid promoted bone formation and osteogenic differentiation in ovariectomized rats through the TFEB autophagy-lysosomal pathway.