Nicotinamide Riboside and Urolithin A Combination for NAD+ Restoration and Mitophagy

Nicotinamide riboside increases cellular NAD+ levels activating SIRT1-mediated PGC-1α deacetylation for enhanced mitochondrial biogenesis, while urolithin A triggers PINK1/PARKIN-mediated selective autophagy of dysfunctional mitochondria lacking functional ACADM, promoting healthy mitochondrial population