Inflammation

Pathway2 papers

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medRxivHumansPreprint

Inflammatory burden links to racial disparities in heart failure

In a 16-year study of 6,785 adults, baseline inflammatory markers accounted for 57.5% of the Black-White log-hazard difference in incident heart…In a 16-year study of 6,785 adults, baseline inflammatory markers accounted for 57.5% of the Black-White log-hazard difference in incident heart failure.

MedicineHumans

Sex hormone-binding globulin raises lumbar fracture risk

Genetically higher SHBG increased lumbar fracture risk with an odds ratio of 1.201 in FinnGen and 1.005 in UK Biobank, mediated primarily by bone…Genetically higher SHBG increased lumbar fracture risk with an odds ratio of 1.201 in FinnGen and 1.005 in UK Biobank, mediated primarily by bone density.

Nature MedicineHuman trial

Semaglutide curbs kidney vascular resistance and fibrosis

In 106 people with diabetes and kidney disease, 52 weeks of semaglutide reduced vascular resistance and stabilized markers of fibrosis compared to…In 106 people with diabetes and kidney disease, 52 weeks of semaglutide reduced vascular resistance and stabilized markers of fibrosis compared to placebo.

MedicineHumans

Genetically predicted TNF-beta protects against sarcopenia traits in humans

A Mendelian randomization analysis of 91 circulating inflammatory markers identified tumor necrosis factor-beta as causally linked to better muscle…A Mendelian randomization analysis of 91 circulating inflammatory markers identified tumor necrosis factor-beta as causally linked to better muscle mass, grip strength, and walking pace.