Cellular senescence

1. Exercise decreases cellular senescence in mice.

   Animalsin doxorubicin-treated miceheart

   Exercise protects mouse hearts from chemotherapy toxicity by suppressing cellular senescence · Research Square · 29 Sep 2026 · Preprint

2. Exercise inhibits cellular senescence.

   Review

   Integrated Multi-Omics Network by Physical Exercise Across Aging: Molecular Adaptation Beyond Single Signaling Pathways · Physiological genomics · 21 Sep 2026

Exercise →

1. Dasatinib + quercetin decreases cellular senescence in humans.

   Human trialfibrotic MASHliver

   Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial · Nature metabolism · 1 Oct 2026

Dasatinib + quercetin →

1. Syringin inhibits cellular senescence in cells.

   Cellsin TGFβ1-stimulated fibroblasts

   Syringin reduces cellular senescence and pulmonary fibrosis in mice and cell models · Chinese journal of natural medicines · 1 Oct 2026

Syringin →

1. Hydrogen sulfide inhibits cellular senescence in mice.

   Animalsin aged mice

   Chemogenetic hydrogen sulfide production reverses vascular remodeling in aged mice · bioRxiv · 30 Sep 2026 · Preprint

Hydrogen sulfide →

1. Calcium chelation decreases cellular senescence in vertebrates cells.

   Cellssenescence stimuli

   Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis · Biochimica et biophysica acta. General subjects · 30 Sep 2026

Calcium chelation →

1. Aged mouse neutrophil conditioned media increases cellular senescence in mouse cells.

   Cellsexposure to conditioned media from aged mouse neutrophils

   Aging remodels mouse neutrophils across organs to drive inflammatory and senescence responses · Aging cell · 30 Sep 2026

Aged mouse neutrophil conditioned media →

1. Irisin decreases cellular senescence in human cells.

   Cellsin doxorubicin-treated human cardiomyocytes and endothelial cells

   Exercise protects mouse hearts from chemotherapy toxicity by suppressing cellular senescence · Research Square · 29 Sep 2026 · Preprint

Irisin →

1. Rapamycin inhibits cellular senescence in human cells.

   Cellsin A549 cells

   Rapamycin slows pulmonary fibrosis by reducing lung epithelial cell senescence in mice · Research Square · 28 Sep 2026 · Preprint

Rapamycin →

1. MCC950 increases cellular senescence in cells.

   Cellsin aged bone marrow-derived macrophages upon LPS stimulation

   NLRP3 inflammasome activity shifts toward regulating cell fate in aged macrophages · Bulletin of experimental biology and medicine · 28 Sep 2026

MCC950 →

1. Quercetin inhibits cellular senescence in rat cells.

   Cellsin arsenic-exposed H9C2 rat cardiomyoblasts60 μM24 h

   Arsenic triggers heart senescence in mice while quercetin counteracts the damage · Toxicology and applied pharmacology · 26 Sep 2026

Quercetin →

1. Cellular senescence decreases HMGCS2 in mice.

   Animalsdiaphragm

   Proteomic and bioinformatic profiling of the aging mouse heart-diaphragm system · European journal of translational myology · 2 Oct 2026

HMGCS2 →

1. Cellular senescence decreases NNT in mice.

   Animalsheart

   Proteomic and bioinformatic profiling of the aging mouse heart-diaphragm system · European journal of translational myology · 2 Oct 2026

NNT →

1. Cellular senescence impairs HFSC-MeSC temporal coordination.

   Review

   The Spatiotemporal Coupling Imbalance of Senescent Grey Hair: Remodelling of the HFSC-MeSC-Niche Network and a New Paradigm of Stem Cell Senescence · Experimental dermatology · 1 Oct 2026

1. Cellular senescence impairs biologic potency of MSCs.

   Review

   Clinical Translation of Mesenchymal Stem Cells to Medicinal Signaling Cells: Origins, Clinical Applications, and the Future of Regenerative Medicine-2026 Arnold I. Caplan Award for Distinguished Research in Orthobiologics · The Journal of the American Academy of Orthopaedic Surgeons · 30 Sep 2026

1. Cellular senescence increases inflammatory monocyte state in human cells.

   Cells

   Transitional senescent monocytes drive age-related inflammation in humans · bioRxiv : the preprint server for biology · 13 Sep 2026 · Preprint

1. Cellular senescence increases hydrogen peroxide in human cells.

   “medium from senescent astrocytes failed to elicit this response and instead promoted hydrogen peroxide accumulation”

   Cellsconditioned medium from senescent astrocyteshuman postmitotic neurons

   Senescent human astrocytes impair neuronal mitochondrial function through released factors · Antioxidants (Basel, Switzerland) · 6 Sep 2026

Hydrogen peroxide →

1. Cellular senescence decreases ATP in human cells.

   “these cells displayed reduced mitochondrial membrane potential, intracellular ATP and cellular metabolic activity”

   Cellsdoxorubicin-induced senescenceprimary human astrocytes

   Senescent human astrocytes impair neuronal mitochondrial function through released factors · Antioxidants (Basel, Switzerland) · 6 Sep 2026

ATP →

1. Cellular senescence decreases fertility.

   Reviewuterus

   The Possibility and Characteristics of Senescence-Related Changes in Reproductive Tissues Such as the Ovary, Oviduct, and Uterus · Reproductive medicine and biology · 1 Jan 2026

1. Cellular senescence impairs reproductive performance.

   Review

   The Possibility and Characteristics of Senescence-Related Changes in Reproductive Tissues Such as the Ovary, Oviduct, and Uterus · Reproductive medicine and biology · 1 Jan 2026

1. HCAR1 prevents cellular senescence in mice.

   Animalsendothelial-specific deletion in young miceartery

   Lactate receptor activation reduces cellular senescence and protects vascular health in mice · bioRxiv · 25 Sep 2026 · Preprint

2. HCAR1 prevents cellular senescence in human cells.

   Cellsin early-passage cells

   Lactate receptor activation reduces cellular senescence and protects vascular health in mice · bioRxiv · 25 Sep 2026 · Preprint

HCAR1 →

1. IL-1 signalling mediates cellular senescence in mice.

   Animalsmacrophage-to-fibroblast pro-senescent signaling

   Prostaglandin E2 drives cellular senescence and scar fibrosis after cesarean section in mice · EMBO molecular medicine · 2 Oct 2026

IL-1 signalling →

1. Upper gastrointestinal cancer increases cellular senescence in humans.

   Humanspre-operatively and post-operatively in UGI patients compared to healthy controls

   Investigating immunological, transcriptomic and metabolomic signatures and their association with pneumonia after upper gastrointestinal cancer surgery · Research Square · 29 Sep 2026 · Preprint

Upper gastrointestinal cancer →

1. UHRF1 induces cellular senescence in zebrafish.

   Animalsin zebrafish hepatocytes

   UHRF1 levels drive distinct senescent states in zebrafish liver cells · EMBO reports · 28 Sep 2026

UHRF1 →

1. GHR prevents cellular senescence in mice.

   “enhanced cellular senescence”

   Animalshepatocyte-specific knockout

   Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice · Aging cell · 26 Sep 2026

GHR →

1. stress-granule mediates cellular senescence.

   Reviewin inflammation-driven senescence

   Stress granules and RNA-binding proteins in cellular senescence: a modular perspective on stress adaptation and inflammation · Molecular biology reports · 25 Sep 2026

1. AGTR2 inhibits cellular senescence in mice.

   Animalsin aged AT2R knockout mice

   Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice · Clinical science (London, England : 1979) · 25 Sep 2026

AGTR2 →

1. conditioned media increases cellular senescence in human cells.

   Cellsconditioned media from 7d-recovery OF vs YF fibroblastsfemales

   Altered cell communication impairs muscle recovery in older women after disuse · bioRxiv : the preprint server for biology · 24 Sep 2026 · Preprint

1. SCAF1 induces cellular senescence in human cells.

   Cellsoverexpressionfibroblast

   Peroxisomal stress drives cellular senescence by relocating SCAF1 to mitochondria · bioRxiv : the preprint server for biology · 23 Sep 2026 · Preprint

SCAF1 →

1. SIRT1 inhibits cellular senescence.

   “SIRT1 levels and activity fall with age, and this decline directly promotes senescence.”

   Review

   SIRT1 in Senescence: Mitochondria and Immune Crosstalk · Biology · 8 Sep 2026

SIRT1 →

1. Cellular senescence is associated with extracellular matrix remodelling in mice.

   Animalsheart and diaphragm muscle

   Proteomic and bioinformatic profiling of the aging mouse heart-diaphragm system · European journal of translational myology · 2 Oct 2026

Extracellular matrix remodelling →

1. Age-conserved kidney transcriptomic signature is associated with cellular senescence in mice.

   Animalskidney55–58 daysfemales

   Spaceflight Is Associated with an Age-Conserved Kidney Transcriptomic Signature Linked to Inflammation, Tubular Channelopathy, and Senescence · Preprints.org · 29 Sep 2026 · Preprint

Age-conserved kidney transcriptomic signature →

1. KRAS is associated with cellular senescence in humans.

   Humanscoronary and carotid plaques

   Senescent CD8 T cells show elevated KRAS in premature coronary artery disease · bioRxiv · 28 Sep 2026 · Preprint

KRAS →

1. Peptides are associated with cellular senescence.

   Reviewin current literature

   Artificial intelligence and in silico discovery of senolytic and senescence-associated food peptides · Food chemistry · 25 Sep 2026

Peptides →

1. Cellular senescence is associated with ligand-receptor interactions in silico.

   “our analysis revealed novel tissue-specific patterns of ligand-receptor interactions between senescent cells and their microenvironment.”

   In silicoin healthy donorsn = 177

   Senescent Cell Heterogeneity: Tissue-Dependent Signatures and Age Dynamics Revealed by Human scRNA-Seq Data · International journal of molecular sciences · 21 Sep 2026

1. Cellular senescence is associated with senescent cell heterogeneity in silico.

   “we identified organ-specific aging features in senescent cells of different cell types.”

   In silicoin healthy donorsn = 177

   Senescent Cell Heterogeneity: Tissue-Dependent Signatures and Age Dynamics Revealed by Human scRNA-Seq Data · International journal of molecular sciences · 21 Sep 2026

1. Lipid and ceramide metabolism is associated with cellular senescence in humans.

   “Dysregulated plasma phospholipid metabolism, particularly involving phosphatidylcholine (PC), lysophosphatidylcholine (LPC), phosphatidylethanolamine (PE), and lysophosphatidylethanolamine (LPE), was associated with T-cell senescence in elderly COVID-19 patients.”

   Humansin elderly COVID-19 patients

   Plasma metabolic shifts link to T-cell senescence and mortality in older COVID-19 patients · Biomedicines · 19 Sep 2026

Lipid and ceramide metabolism →