AMPK signalling
Pathway23 papers5 findings
Studies in mice and Dictyostelium discoideum show that pharmacological agents activate AMPK signalling. Reviews also link berberine and intermittent fasting to activation of this pathway.
- Animals5
- Model organisms1
- Cells4
- In silico1
Interventions
5MK-8722
upin mice1
1 study
MK-8722
upin mice1
MK-8722 activates AMPK signalling in mice.
Animalsin APP/PS1 miceliver
Pan-AMPK activator MK-8722 improves spatial memory in Alzheimer's model mice · Journal of neurochemistry · 1 Oct 2026
4-octyl itaconate
upin mice1
1 study
4-octyl itaconate
upin mice1
4-octyl itaconate activates AMPK signalling in mice.
Animalsparotid gland25 mg/kg4 weeksmales
4-Octyl itaconate restores parotid gland function in aging mice · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 30 Sep 2026
Berberine
upin reviews1
1 study
Berberine
upin reviews1
Berberine activates AMPK signalling.
Review
Berberine as a multi-hallmark modulator of aging: From AMPK and mitophagy to inflammaging and the SASP · Fitoterapia · 28 Sep 2026
Intermittent fasting
upin reviews1
1 study
Intermittent fasting
upin reviews1
Intermittent fasting activates AMPK signalling.
Review
Intermittent and periodic fasting: molecular mechanisms, health benefits and research challenges · Frontiers in nutrition · 15 Sep 2026
Metformin
upin D. discoideum1
1 study
Metformin
upin D. discoideum1
Metformin activates AMPK signalling in D. discoideum.
“Gene-expression analysis revealed the upregulation of AMP-activated protein kinase (AMPK) and core autophagy genes, indicating activation of an AMPK-linked pro-autophagy pathway involved in aggregate clearance.”
Model organisms
Drug-Induced Reduction in 80Q Aggregates in a Dictyostelium discoideum Model of PolyQ Disease · Biomedicines · 28 Aug 2026
Latest
23Pan-AMPK activator MK-8722 improves spatial memory in Alzheimer's model mice
Systemic treatment activated liver AMPK, restored plasma metabolites, and enhanced dendritic spine maturation without altering hippocampal long-term potentiation.
Journal of neurochemistry · Nicol NI et al.
AMPK lengthens the circadian clock period through NAD+-dependent regulation of Bmal1
Experiments in human cells and computational modeling show that fasting sensor AMPK requires NAD+ and PGC-1-alpha to modulate cellular circadian rhythms.
bioRxiv · Vandenberghe A et al.
The Role of Natural Products in Ameliorating Mitochondrial Dysfunction in Diabetic Kidney Disease and the Underlying Mechanisms
Intermittent and periodic fasting: molecular mechanisms, health benefits and research challenges
Mitohormesis linking metabolic dysfunction and neurodegeneration: implications for dementia and therapeutic strategies
4-Octyl itaconate restores parotid gland function in aging mice
The itaconate derivative reduces fibrosis and lipid buildup while curbing oxidative stress through AMPK signaling pathways.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · Chen Y et al.
Direct AMPK activation extends lifespan across yeast, worms, and flies
Treatment with the direct activator 991 also induced a pro-longevity proteomic profile in mice.
Aging cell · Dos Santos E et al.