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Mitoquinone

Intervention

4 papers2 findings

MeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 2 countries
  • Funders: National Cancer Institute and 2 more
  • 1 of 2 findings with company ties
  • Animals3
  • Cells1

Outcomes

2

Cellular senescence

downin human cells1

1 study

  1. Mitoquinone decreases cellular senescence in human cells.

    “However, the level of p21 and/or Bcl-xL was decreased in hyperoxia-exposed cells treated with the ER stress inhibitor salubrinal or the antioxidant MitoQ”

    Cellsin hyperoxia-exposed fetal airway smooth muscle cells100 nM

    Hyperoxia-induced senescence in fetal airway smooth muscle cells: role of mitochondrial reactive oxygen species and endoplasmic reticulum stress

    American journal of physiology. Lung cellular and molecular physiology4 Apr 2025

More on Cellular senescence

[18F]BCPP-EF uptake

downin rats1

1 study

  1. Mitoquinone decreases [18F]BCPP-EF uptake in rats.

    “this high uptake in aged rats was suppressed by mitoquinone, a superoxide scavenger”

    Animalsovaryfemales

    [¹⁸F]BCPP-EF positron emission tomography of rat ovaries for evaluation of mitochondrial function

    Nuclear medicine and biology22 Jan 2025

More on [18F]BCPP-EF uptake

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