Mitochondrial fission and fusion
Pathway8 papers1 findingMeSH D063154GO 0000266
- Human trial1
- Animals3
- Cells1
Associations
1Selection against deleterious mtDNA variants
mixedin mice1
1 study
Selection against deleterious mtDNA variants
mixedin mice1
Mitochondrial fission and fusion is associated with selection against deleterious mtDNA variants in mice.
Animals
Early-life mitochondrial DNA mutations drive age-related pathology in mice · bioRxiv · 27 Sep 2026 · Preprint
Latest
8The effects of chronic beetroot juice supplementation with resistance training on skeletal muscle mitochondrial and redox markers in middle-aged and older adults
Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice
Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and…Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance.
Early-life mitochondrial DNA mutations drive age-related pathology in mice
Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.
Mitochondrial-Targeted Phytochemicals in Reproductive Aging: Mechanisms and Translational Potential
Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance
The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.
Senescent human astrocytes impair neuronal mitochondrial function through released factors
Conditioned medium from damaged astrocytes alters extracellular mitochondria and triggers ATP depletion and oxidative stress in human postmitotic…Conditioned medium from damaged astrocytes alters extracellular mitochondria and triggers ATP depletion and oxidative stress in human postmitotic neurons.