Apoptosis
Pathway27 papers8 findingsGO 0006915
In cell, mouse, and chicken studies, diverse interventions modulate apoptosis, with specific treatments inhibiting cell death across tissues while chemical stress induces it in human and mouse cells. Reviews link mitochondrial dysfunction and natural products to its regulation.
- Animals10
- Model organisms2
- Cells2
Interventions
6N-methyl-n-nitrosourea
upin human cells1upin mouse cells1
1 study
N-methyl-n-nitrosourea
upin human cells1upin mouse cells1
N-methyl-n-nitrosourea induces apoptosis in mouse cells.
Cellsmesenchymal stem cell
Blind mole-rat mesenchymal stem cells resist carcinogen-induced damage through preserved p53 signaling · Stem cells (Dayton, Ohio) · 25 Sep 2026
N-methyl-n-nitrosourea induces apoptosis in human cells.
Cellsmesenchymal stem cell
Blind mole-rat mesenchymal stem cells resist carcinogen-induced damage through preserved p53 signaling · Stem cells (Dayton, Ohio) · 25 Sep 2026
Natural products
downin reviews1
1 study
Natural products
downin reviews1
Natural products inhibit apoptosis.
Reviewvia Bcl-2/Bax/caspase signalingkidney
The Role of Natural Products in Ameliorating Mitochondrial Dysfunction in Diabetic Kidney Disease and the Underlying Mechanisms · Mini reviews in medicinal chemistry · 30 Sep 2026
Aging-resistant ionogel dressing
downin mice1
1 study
Aging-resistant ionogel dressing
downin mice1
Aging-resistant ionogel dressing inhibits apoptosis in mice.
Animalssenescent microenvironmentskin
A magnesium-phenolic hydrogel accelerates wound healing in aged mice · ACS applied materials & interfaces · 28 Sep 2026
MCC950
downin cells1
1 study
MCC950
downin cells1
MCC950 decreases apoptosis in cells.
Cellsduring agingbone marrow-derived macrophages
NLRP3 inflammasome activity shifts toward regulating cell fate in aged macrophages · Bulletin of experimental biology and medicine · 28 Sep 2026
Erigeron breviscapus
downin mice1
1 study
Erigeron breviscapus
downin mice1
Erigeron breviscapus inhibits apoptosis in mice.
Animalsin SAMP8 mice
Erigeron breviscapus extends worm lifespan and reduces senescence markers in mice · Biogerontology · 25 Sep 2026
FOXO3 overexpression
downin chickens1
1 study
FOXO3 overexpression
downin chickens1
FOXO3 overexpression decreases apoptosis in chickens.
Animalsat 3 dphovaryfemales
FOXO3 overexpression delays primordial follicle activation in chickens · Poultry science · 21 Sep 2026
Upstream
1Mitochondrial dysfunction
upin reviews1
1 study
Mitochondrial dysfunction
upin reviews1
Mitochondrial dysfunction activates apoptosis.
Review
Redox-Mitochondrial Crosstalk in Neurotoxicity: Regulated Cell Death Pathways and Neuroprotective Strategies · Ageing research reviews · 30 Sep 2026
Latest
29Senescent CD4 T cells drive age-associated autoimmunity in mice and humans
Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.
bioRxiv : the preprint server for biology · McCarthy EC et al.
Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice
TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.
Aging cell · Chen G et al.
The therapeutic potential of melatonin: Focus on the SIRT1 signaling pathway
Renovascular Disease and Its Impact on Endogenous Kidney Repair: Stem/Progenitor Cells
The Role of Natural Products in Ameliorating Mitochondrial Dysfunction in Diabetic Kidney Disease and the Underlying Mechanisms
D-allose attenuates intervertebral disc degeneration by targeting a mitochondrial stress pathway
The rare sugar enhances mitophagy, blocks cGAS-STING signaling, and protects nucleus pulposus cells from senescence and apoptosis.
Experimental & molecular medicine · Zhao Z et al.
Redox-Mitochondrial Crosstalk in Neurotoxicity: Regulated Cell Death Pathways and Neuroprotective Strategies
FOXO3 overexpression delays primordial follicle activation in chickens
Overexpressing the transcription factor kept avian follicles dormant and suppressed PI3K and AKT signaling during early ovarian development.
Poultry science · Lan M et al.