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Royal jelly

Intervention

2 papers8 findings

MeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 1 country
  • 1 finding against
  • Funder: Japan Society for the Promotion of Science
  • 3 of 8 findings with company ties
  • Animals2

Outcomes

7

Lifespan

no changein mice1upin mice1+25%

1 study

  1. Royal jelly has no effect on lifespan in mice.

    “However, RJ did not extend the total life span.”

    Animals

    Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage

    Experimental gerontology1 Sep 2003

  2. Royal jelly extends lifespan in mice (about 25%).

    “RJ extended the average survival time by about 25% compared to the control group”

    Animals

    Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage

    Experimental gerontology1 Sep 2003

PI3K–AKT signalling

upin mouse cells1

1 study

  1. Royal jelly activates PI3K–AKT signalling in mouse cells.

    “pRJ treatment increased the cell proliferation rate, promoted cell differentiation, and activated Akt intracellular signaling pathway compared with controls”

    Cellsisolated satellite cells from aged miceprotease-treatedsatellite cell

    Royal jelly prevents the progression of sarcopenia in aged mice in vivo and in vitro

    The journals of gerontology. Series A, Biological sciences and medical sciences8 May 2013

More on PI3K–AKT signalling

IGF-1

upin mice1

1 study

  1. Royal jelly increases IGF-1 in mice.

    “increased the regenerating capacity of injured muscles and the serum insulin-like growth factor-1 levels compared with controls”

    Animals

    Royal jelly prevents the progression of sarcopenia in aged mice in vivo and in vitro

    The journals of gerontology. Series A, Biological sciences and medical sciences8 May 2013

More on IGF-1

Muscle regeneration

upin mice1

1 study

  1. Royal jelly increases muscle regeneration in mice.

    “increased the regenerating capacity of injured muscles and the serum insulin-like growth factor-1 levels compared with controls”

    Animalsinjured muscles

    Royal jelly prevents the progression of sarcopenia in aged mice in vivo and in vitro

    The journals of gerontology. Series A, Biological sciences and medical sciences8 May 2013

Grip strength

upin mice1

1 study

  1. Royal jelly improves grip strength in mice.

    “attenuated the decrease in the muscle weight and grip strength”

    Animalsaged mice

    Royal jelly prevents the progression of sarcopenia in aged mice in vivo and in vitro

    The journals of gerontology. Series A, Biological sciences and medical sciences8 May 2013

Muscle weight

upin mice1

1 study

  1. Royal jelly increases muscle weight in mice.

    “RJ/pRJ treatment attenuated the decrease in the muscle weight and grip strength”

    Animalsaged mice

    Royal jelly prevents the progression of sarcopenia in aged mice in vivo and in vitro

    The journals of gerontology. Series A, Biological sciences and medical sciences8 May 2013

8-hydroxy-2'-deoxyguanosine

downin mice1

1 study

  1. Royal jelly decreases 8-hydroxy-2'-deoxyguanosine in mice.

    “levels of 8-hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative stress, were significantly reduced in kidney DNA and serum”

    Animalskidney16 weeks

    Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage

    Experimental gerontology1 Sep 2003

More on 8-hydroxy-2'-deoxyguanosine

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