Mitochondrial DNA maintenance
Pathway4 papersGO 0032042
- Humans1
- Animals2
Latest
4Darker skin pigmentation links to fewer mitochondrial DNA mutations from sun exposure
Melanin protects against mitochondrial genome damage and clonal expansion in chronically sun-exposed human skin.Melanin protects against mitochondrial genome damage and clonal expansion in chronically sun-exposed human skin.
An Update of Oxidative Stress in Atherosclerosis with Emphasis on the LOX-1-NLRP3 Inflammasome Axis
Early-life mitochondrial DNA mutations drive age-related pathology in mice
Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.
TFAM deficiency in T cells worsens viral lung pathology and weakens immunity
Declining TFAM levels impair mitochondrial function in CD8+ T cells, driving tissue damage and weakening long-term immune protection during influenza.Declining TFAM levels impair mitochondrial function in CD8+ T cells, driving tissue damage and weakening long-term immune protection during influenza.