Combined Downregulation of Insulin and Mitochondrial Signaling Leads to Synergistic Life- and Healthspan Extension in Caenorhabditis Elegans

Abstract

The Caenorhabditis elegans insulin/IGF-1 signaling (IIS) pathway functions as both a rheostat for nutrient levels and as an evolutionarily conserved mechanism likely to shed light on its functions and regulation in higher organisms. Early studies in C.