Atherosclerosis
Disease7 papers6 findingsMeSH D050197
In mouse models, alpha-synuclein promotes atherosclerosis, whereas Snca knockout, salvianolic acid A, and HSP90AA1 knockdown reduce disease burden. Additionally, reviews associate atherosclerosis with impaired clearance of ferroptotic foam cells and link it to human genomic instability.
- Animals3
Interventions
4Alpha-synuclein
upin mice1
1 study
Alpha-synuclein
upin mice1
Alpha-synuclein increases atherosclerosis in mice.
“administration of exogenous α-Syn accelerated atherosclerosis in Apolipoprotein E knockout (Apoe -/- ) mice.”
Animalsin Apolipoprotein E knockout (Apoe -/- ) miceexogenous
Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy · Aging cell · 29 Sep 2026
Snca knockout
downin mice1
1 study
Snca knockout
downin mice1
Snca knockout decreases atherosclerosis in mice.
“Genetic deletion of α-Syn reduced atherosclerotic lesion size and macrophage lipid accumulation in a mouse model of atherosclerosis induced by overexpression of proprotein convertase subtilisin/kexin type 9 (PCSK9).”
Animalsinduced by overexpression of PCSK9
Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy · Aging cell · 29 Sep 2026
HSP90AA1 knockdown
downin mice1
1 study
HSP90AA1 knockdown
downin mice1
HSP90AA1 knockdown protects against atherosclerosis in mice.
“VSMC-specific HSP90α knockdown mimicked the protective effects of SAA, whereas HSP90α overexpression reversed SAA-mediated effects on disease.”
AnimalsVSMC-specific knockdown in ApoE -/- miceadeno-associated virus-mediatedvascular smooth muscle cell
Salvianolic acid A eases atherosclerosis in mice by eliminating senescent vascular cells · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026
Salvianolic acid a
downin mice1
1 study
Salvianolic acid a
downin mice1
Salvianolic acid a protects against atherosclerosis in mice.
“decreased the size of plaque, and increased the stability of the fibrous cap.”
Animalsin ApoE -/- mice fed a high-fat diet
Salvianolic acid A eases atherosclerosis in mice by eliminating senescent vascular cells · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026
Upstream
1Ferroptosis
upin reviews1
1 study
Ferroptosis
upin reviews1
Ferroptosis increases atherosclerosis.
“oxidized lipids, cellular debris, and inflammatory signals accumulate, promoting secondary necrosis, necrotic core expansion, plaque non-resolution, and instability.”
Reviewwhen dying foam cells are not efficiently cleared
Mitochondrial Redox Failure Links Senescence-like Foam Cell Stress to Ferroptosis and Plaque Non-Resolution in Atherosclerosis · Antioxidants (Basel, Switzerland) · 25 Aug 2026
Associations
1Genomic instability
upin humans1
1 study
Genomic instability
upin humans1
Genomic instability is associated with atherosclerosis in humans.
Reviewclonal evolution in tissue microenvironmentatherosclerotic plaque
Inherited and somatic components in the pathogenetics of common diseases · Vavilovskii zhurnal genetiki i selektsii · 1 Sep 2026
Latest
11Rapamycin reduces ferroptotic stress and shrinks atherosclerotic plaques in mice
The mTOR inhibitor restored macrophage efferocytosis and mitochondrial function while lowering aortic lipid burden in high-fat-fed ApoE-deficient mice.
International immunopharmacology · Wang Y et al.
Inherited and somatic components in the pathogenetics of common diseases
ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification
Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.
medRxiv · Small A et al.
Chemogenetic hydrogen sulfide production reverses vascular remodeling in aged mice
Targeting hydrogen sulfide generation to endothelial mitochondria mitigated senescence programs and reversed vascular remodeling in aged mice.
bioRxiv · Shabanian K et al.
An Update of Oxidative Stress in Atherosclerosis with Emphasis on the LOX-1-NLRP3 Inflammasome Axis
Senescent CD8 T cells show elevated KRAS in premature coronary artery disease
Analyses of human blood and plaque samples link KRAS-driven immunosenescence and cell cytotoxicity to early cardiovascular disease.
bioRxiv · Sun Z et al.
Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy
Targeting FLOT1 or downstream PI3K-mTOR signaling counteracted the vascular lipid accumulation driven by extracellular alpha-synuclein in mouse models.
Aging cell · Qin M et al.
Salvianolic acid A eases atherosclerosis in mice by eliminating senescent vascular cells
The compound disrupts an HSP90α complex to trigger endoplasmic reticulum stress and selectively induce apoptosis in senescent smooth muscle cells.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Guan X et al.