TGF-β signalling
Pathway12 papers2 findingsGO 0007179
- Humans2
- Animals5
- Cells4
Upstream
1Clonal hematopoiesis of indeterminate potential
upin human cells1
1 study
Clonal hematopoiesis of indeterminate potential
upin human cells1
Clonal hematopoiesis of indeterminate potential activates TGF-β signalling in human cells.
Cellsbone marrow
Clonal hematopoiesis remodels human bone marrow into an inflammatory prefibrotic environment · Nature immunology · 30 Sep 2026
Associations
1Female infertility
upin humans1
1 study
Female infertility
upin humans1
TGF-β signalling is associated with female infertility in humans.
“Fibro-inflammatory pathways, including transforming growth factor-β (TGF-β), Hippo/YAP-TAZ signaling, oxidative stress, macrophage activation, and mechanotransduction, are increasingly associated with ovarian ageing, polycystic ovary syndrome, reduced ovarian reserve”
Reviewovaryfemales
The Fibro-Inflammatory Ovary: Stromal Fibrosis, Extracellular Matrix Remodeling, and Mechanotransduction in Female Infertility · Current issues in molecular biology · 8 Sep 2026
Latest
13Altered cell communication impairs muscle recovery in older women after disuse
Single-nucleus sequencing reveals disrupted signaling between satellite cells and fibro-adipogenic progenitors during muscle regrowth in older females.
bioRxiv : the preprint server for biology · Skiles CM et al.
Senescent prostate cancer cells drive stromal remodeling through TGF-beta signaling
Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment can blunt.
Neoplasia (New York, N.Y.) · Lin C et al.
Clonal hematopoiesis remodels human bone marrow into an inflammatory prefibrotic environment
Single-cell and spatial profiling revealed expanded fibroblasts and localized hubs of inflammation driven by tumor necrosis factor and transforming growth factor-beta signaling.
Nature immunology · Aguilar-Navarro AG et al.
Syringin reduces cellular senescence and pulmonary fibrosis in mice and cell models
Computational screening identified the natural compound, which interacts with CHK1 to blunt replication stress and fibrotic signaling.
Chinese journal of natural medicines · Wang Y et al.
[Wuzi Yanzong Pill ameliorates diminished ovarian reserve in mice by inhibiting granulosa cell apoptosis via the TGF-β1/PI3K/Akt/mTOR pathway]
Parthenolide reduces senescence and skin fibrosis in scleroderma models
The compound targets Ero1L to stabilize contacts between mitochondria and the endoplasmic reticulum, mitigating tissue damage in cells and mice.
Aging cell · Wang F et al.
IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice
Targeting this pathway curbs mitochondrial oxidative stress and pericyte activation to partially restore auditory function in mouse models.
Aging cell · Xu R et al.
Activin A from inflammatory macrophages impairs stem cell regulation in aging human muscle
Researchers mapped signaling pathways between senescent-like immune cells and muscle stem cells across multiple human transcriptomic datasets.
International journal of molecular sciences · Liu X et al.