Reproductive system
Body system92 papersUBERON 0000990
- Human trial8
- Humans32
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92Prostaglandin E2 drives cellular senescence and scar fibrosis after cesarean section in mice
Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean…Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean defects.
Calcium overload impairs muscle regeneration by driving sustained NFAT signaling
Inhibiting NFAT restored myoblast differentiation in culture and improved myofiber repair in injured mice.Inhibiting NFAT restored myoblast differentiation in culture and improved myofiber repair in injured mice.
Elamipretide improves oocyte quality and restores fertility in aged mice
The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway.The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway.
Nettle cream improves sexual quality of life in menopause
Adjusted sexual quality of life scores were 7.7 points higher with nettle cream than with placebo after eight weeks of treatment.Adjusted sexual quality of life scores were 7.7 points higher with nettle cream than with placebo after eight weeks of treatment.
Model-based evaluation of an infant HPV prophylactic vaccination program in Nigeria
Digital health innovations: imagining opportunities to support people with a learning disability experiencing menopause
Performance of a multi-biomarker class, multi-cancer early detection (MCED) blood test in a prospectively collected cohort
Senescent prostate cancer cells drive stromal remodeling through TGF-beta signaling
Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment…Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment can blunt.
Inhibiting CHK2 improves oocyte quality and reduces ovarian inflammation in aged mice
A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte…A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.
Diet Composition Modifies Cardiometabolic Phenotype Development in the 4-Vinylcyclohexene Dioxide (VCD) Ovarian Failure Model of Menopause
Factors influencing compliance with cervical cancer screening guidelines among women aged 30 to 49 years in Morocco
Stress and recovery dynamics reveal transcriptomic stability limits across aging mouse organs
Researchers used sleep deprivation and neural ordinary differential equations to track organ gene expression shifts and recovery boundaries in young…Researchers used sleep deprivation and neural ordinary differential equations to track organ gene expression shifts and recovery boundaries in young and aged mice.
Declining ribosome function drives reproductive aging in fruit fly and mouse oocytes
A genetic screen and functional assays show that falling translational capacity causes meiotic and developmental defects during oocyte aging.A genetic screen and functional assays show that falling translational capacity causes meiotic and developmental defects during oocyte aging.