cGAS–STING signalling
Pathway9 papers5 findingsGO 0140896
In human and mouse cell studies, cGAS–STING signalling is inhibited by D-allose and activated by Prodh2. Reviews link the pathway to cellular senescence in humans and associate it with chronic inflammation and SASP induction in the aging brain.
- Humans1
- Animals5
Interventions
1D-allose
downin human cells1
1 study
D-allose
downin human cells1
D-allose inhibits cGAS–STING signalling in human cells.
Cellsnucleus pulposus cell
D-allose attenuates intervertebral disc degeneration by targeting a mitochondrial stress pathway · Experimental & molecular medicine · 1 Oct 2026
Effects
2Senescence-associated secretory phenotype (SASP)
upin reviews1
1 study
Senescence-associated secretory phenotype (SASP)
upin reviews1
cGAS–STING signalling induces senescence-associated secretory phenotype (SASP).
Reviewbrain
[Mechanisms of cGAS-STING-mediated chronic inflammation and targeted interventions in brain aging] · Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 1 Jul 2026
Chronic inflammation
upin reviews1
1 study
Chronic inflammation
upin reviews1
cGAS–STING signalling activates chronic inflammation.
Reviewduring brain agingbrain
[Mechanisms of cGAS-STING-mediated chronic inflammation and targeted interventions in brain aging] · Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 1 Jul 2026
Upstream
1Prodh2
upin mouse cells1
1 study
Prodh2
upin mouse cells1
Prodh2 activates cGAS–STING signalling in mouse cells.
Cellsvia mitochondrial reactive oxygen species and cytosolic mtDNA releasemyoblast
Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice · Aging cell · 1 Oct 2026
Associations
1Cellular senescence
upin humans1
1 study
Cellular senescence
upin humans1
cGAS–STING signalling is associated with cellular senescence in humans.
Reviewassociated with stress granule biology
Stress granules and RNA-binding proteins in cellular senescence: a modular perspective on stress adaptation and inflammation · Molecular biology reports · 25 Sep 2026
Latest
9Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice
Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.
bioRxiv · R. Carvalho D et al.
Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice
TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.
Aging cell · Chen G et al.
D-allose attenuates intervertebral disc degeneration by targeting a mitochondrial stress pathway
The rare sugar enhances mitophagy, blocks cGAS-STING signaling, and protects nucleus pulposus cells from senescence and apoptosis.
Experimental & molecular medicine · Zhao Z et al.
[Mechanisms of cGAS-STING-mediated chronic inflammation and targeted interventions in brain aging]
Crebanine protects aged rats from anesthesia-induced cognitive deficits by restoring mitophagy
The compound suppresses mitochondrial DNA leakage and the cGAS-STING inflammatory pathway in microglial cells following sevoflurane exposure.
Research Square · Zheng G et al.
Targeted nanoplatform reduces microglial senescence and eases motor deficits in Parkinson mice
Silencing the upregulated gene PLXDC2 via brain-penetrating nanoparticles suppressed cGAS-STING signaling, reduced iron accumulation, and protected dopaminergic neurons.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Lu H et al.