Polystyrene nanoplastics

2 papers12 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

4 independent labs in 2 countries

Funders: National Natural Science Foundation of China and 5 more

Animals2

Outcomes

Sperm quality

downin mice2

2 studies

Polystyrene nanoplastics impair sperm quality in mice.
“PS-NPs exposure led to disrupted testicular architecture, decreased sperm quality, and induced spermatocyte senescence in a concentration-dependent manner.”
Animalsvia tracheal instillationmales
YTHDF3-Dependent m⁶A Modification of cGAS Drives Nanoparticle-Induced Senescence in Spermatocytes
Andrology20 Aug 2026
Polystyrene nanoplastics decrease sperm quality in mice.
“declined sperm quality”
Animalstestis3 monthsmales
Multi-omics analysis of testis after long-term exposure to polystyrene nanoplastics reveals premature testicular aging and age-dependent damage in mice
Particle and fibre toxicology23 Oct 2025

Cellular senescence

upin human cells1upin mice1

2 studies

Polystyrene nanoplastics induce cellular senescence in mice.
“indirectly blocking the cell cycle by inhibiting DNA repair, which ultimately leads to splenocyte senescence”
Animals100 nmspleenone or two weeks
Airborne polystyrene nanoplastic exposure leads to splenic cell senescence and immune imbalance
Ecotoxicology and environmental safety15 Jan 2026
Polystyrene nanoplastics induce cellular senescence in human cells.
“Exposure to PS-NPs (50-250 μg/mL) triggered concentration-dependent cellular senescence in KGN cells”
Cellsin KGN cells50-250 μg/mL
Polystyrene nanoplastics induce ovarian granulosa cell senescence via autophagy suppression
NanoImpact6 Dec 2025