Extracellular matrix remodelling
Pathway32 papers6 findingsGO 0030198
- Human trial2
- Humans10
- Animals10
- Model organisms1
- Cells3
Interventions
2Chba
upin mice1
1 study
Chba
upin mice1
Chba improves extracellular matrix remodelling in mice.
Animalsartery
Lactate receptor activation reduces cellular senescence and protects vascular health in mice · bioRxiv · 25 Sep 2026 · Preprint
Jianwei shoutai pill
downin mice1
1 study
Jianwei shoutai pill
downin mice1
Jianwei shoutai pill decreases extracellular matrix remodelling in mice.
Animalsin aged miceuterus
Jianwei Shoutai Pills reduce uterine aging and pregnancy loss in aged mice · Phytomedicine : international journal of phytotherapy and phytopharmacology · 16 Sep 2026
Upstream
2Senescence-associated secretory phenotype (SASP)
upin reviews1
1 study
Senescence-associated secretory phenotype (SASP)
upin reviews1
Senescence-associated secretory phenotype (SASP) induces extracellular matrix remodelling.
Review
Cellular senescence: six decades of discovery and reinvention · The EMBO journal · 2 Oct 2026
Clonal hematopoiesis
upin humans1
1 study
Clonal hematopoiesis
upin humans1
Clonal hematopoiesis increases extracellular matrix remodelling in humans.
Humansbone marrow
Clonal hematopoiesis remodels human bone marrow into an inflammatory prefibrotic environment · Nature immunology · 30 Sep 2026
Associations
2Cellular senescence
upin mice1
1 study
Cellular senescence
upin mice1
Cellular senescence is associated with extracellular matrix remodelling in mice.
Animalsheart and diaphragm muscle
Proteomic and bioinformatic profiling of the aging mouse heart-diaphragm system · European journal of translational myology · 2 Oct 2026
Human skin aging
mixedin humans1
1 study
Human skin aging
mixedin humans1
Human skin aging is associated with extracellular matrix remodelling in humans.
Review
Proteomics of Human Skin Aging: Biological Signatures, Proteoform-Aware Interpretation, and Translational Boundaries for Topical Interventions · Preprints.org · 28 Sep 2026 · Preprint
Latest
36Human aortic elastin degrades with age in males but not females
In 17 human thoracic aorta samples, elastin stiffness, straightness, and lamellar length decreased significantly with age in males (p < 0.05) but not…In 17 human thoracic aorta samples, elastin stiffness, straightness, and lamellar length decreased significantly with age in males (p < 0.05) but not females.
Jianwei Shoutai Pills reduce uterine aging and pregnancy loss in aged mice
The herbal formula delayed thymic involution, restored regulatory T cell function, and improved maternal-fetal immune tolerance by altering metabolic…The herbal formula delayed thymic involution, restored regulatory T cell function, and improved maternal-fetal immune tolerance by altering metabolic signaling in aging female mice.
Semaglutide curbs kidney vascular resistance and fibrosis
In 106 people with diabetes and kidney disease, 52 weeks of semaglutide reduced vascular resistance and stabilized markers of fibrosis compared to…In 106 people with diabetes and kidney disease, 52 weeks of semaglutide reduced vascular resistance and stabilized markers of fibrosis compared to placebo.
Tamoxifen causes temporary ovarian disruption without altering long-term mouse aging trajectories
A new preprint shows tamoxifen-inducible mouse models remain valid for ovarian aging research despite transient disruptions to estrous cycling.A new preprint shows tamoxifen-inducible mouse models remain valid for ovarian aging research despite transient disruptions to estrous cycling.
Proteomic and bioinformatic profiling of the aging mouse heart-diaphragm system
Ovarian stiffness and fibrosis mark reproductive aging in women
Shear wave elastography and transcriptomic profiling show that ovarian fibrosis correlates with reduced oocyte yield and follicular efficiency.Shear wave elastography and transcriptomic profiling show that ovarian fibrosis correlates with reduced oocyte yield and follicular efficiency.
Ovarian stiffness increases with age and tracks with declining egg yield
Researchers combined imaging, matrix profiling, and single-cell sequencing to show how ovarian fibrosis develops in women over time.Researchers combined imaging, matrix profiling, and single-cell sequencing to show how ovarian fibrosis develops in women over time.
Aged perivascular fat increases aortic stiffness and collagen deposition in mice
Removing surrounding adipose tissue reduced stiffness in aged mouse aortas, pointing to fat fibrosis as a contributor to arterial stiffening.Removing surrounding adipose tissue reduced stiffness in aged mouse aortas, pointing to fat fibrosis as a contributor to arterial stiffening.
Senescent prostate cancer cells drive stromal remodeling through TGF-beta signaling
Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment…Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment can blunt.