CDKN1A
Gene16 papers1 findingHGNC 1784MGI 104556NCBI Gene 1026Taxon 9606
- Humans1
- Animals10
- Cells5
Interventions
1Ormeloxifene
upin human cells1
1 study
Ormeloxifene
upin human cells1
Ormeloxifene increases CDKN1A in human cells.
CellsMCF-7
Ormeloxifene, a non-steroidal selective estrogen receptor modulator induces senescence in breast cancer cells · Molecular biology reports · 1 Oct 2026
Latest
16Senescent CD4 T cells drive age-associated autoimmunity in mice and humans
Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.
DNA methylation proxies of senescence markers track human disease and mortality
The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.
Ormeloxifene, a non-steroidal selective estrogen receptor modulator induces senescence in breast cancer cells
A distinct p21-driven macrophage senotype accumulates during aging and liver disease
Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with…Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.
Stress-Induced Senescence of Human Umbilical Cord Mesenchymal Stromal Cells Caused by Mitomycin C
Loss of PP4 drives airway senescence through endoplasmic reticulum stress
Inhibiting the PERK pathway lowered cellular senescence and inflammatory markers in mouse models and cultured human airway cells.Inhibiting the PERK pathway lowered cellular senescence and inflammatory markers in mouse models and cultured human airway cells.
Arsenic triggers heart senescence in mice while quercetin counteracts the damage
Exposure to environmental arsenic caused heart dysfunction via the p53 and p21 pathway, which quercetin treatment reversed in cultured rat…Exposure to environmental arsenic caused heart dysfunction via the p53 and p21 pathway, which quercetin treatment reversed in cultured rat cardiomyoblasts.