Acetylcysteine

InterventionApproved 19633 papers1 findingPubChem 12035ChEBI 28939

Humans1
Cells1

Outcomes

Age-related macular degeneration

no changein humans1HR 1.5Very low certainty

1 study

Acetylcysteine has no effect on age-related macular degeneration in humans (HR 1.50, 95% CI 0.61-3.67).
Humansmatched cohort91 or more consecutive days
N-acetylcysteine Use and Risk of Age-Related Macular Degeneration in a Large United States Cohort · Research Square · 15 Sep 2026 · Preprint

Age-related macular degeneration →

Trials

288

Approved

FDA · Mucomyst
14 Sep 1963 · Discontinued
FDA · Acetadote
23 Jan 2004 · Acetylcysteine Injection is indicated to prevent or lessen hepatic injury after ingestion of a potentially hepatotoxic quantity of…
FDA · Cetylev
29 Jan 2016 · Discontinued

In trials

Chronic Renal Insufficiency
Phase 4 · Completed · 9 trials
Alcoholism
Phase 4 · Recruiting · 8 trials
Acute kidney injury
Phase 4 · Suspended · 7 trials
Chronic Kidney Failure
Phase 4 · Status unknown · 6 trials
Renal insufficiency
Phase 4 · Completed · 6 trials
Autism spectrum disorder
Phase 4 · Results posted · 5 trials

40 of 145

Chronic obstructive pulmonary disease
Phase 4 · Completed · 5 trials
Diabetes mellitus
Phase 4 · Terminated · 5 trials
Marijuana Abuse
Phase 4 · Results posted · 5 trials
Schizophrenia
Phase 4 · Results posted · 5 trials
Tobacco use disorder
Phase 4 · Results posted · 5 trials
Alcoholic Hepatitis
Phase 4 · Status unknown · 4 trials
Bipolar disorder
Phase 4 · Results posted · 4 trials
Kidney disease
Phase 4 · Completed · 4 trials
Obsessive-compulsive disorder
Phase 4 · Active, not recruiting · 4 trials
Ototoxicity
Phase 4 · Terminated · 4 trials
Autistic Disorder
Phase 4 · Results posted · 3 trials
Cardiovascular disease
Phase 4 · Suspended · 3 trials
Infection
Phase 4 · Recruiting · 3 trials
Psychotic disorders
Phase 4 · Results posted · 3 trials
Substance-related disorders
Phase 4 · Results posted · 3 trials
Tuberculosis
Phase 4 · Status unknown · 3 trials
Type 2 diabetes
Phase 4 · Terminated · 3 trials
Alcoholic liver disease
Phase 4 · Status unknown · 2 trials
Coronary artery disease
Phase 4 · Completed · 2 trials
Cystic Fibrosis
Phase 4 · Terminated · 2 trials
Insulin resistance
Phase 4 · Completed · 2 trials
Jaundice
Phase 4 · Status unknown · 2 trials
Liver disease
Phase 4 · Recruiting · 2 trials
Polycystic ovary syndrome
Phase 4 · Completed · 2 trials
Recurrence
Phase 4 · Status unknown · 2 trials
Reperfusion Injury
Phase 4 · Completed · 2 trials
Sepsis
Phase 4 · Recruiting · 2 trials
Tinnitus
Phase 4 · Terminated · 2 trials
Anemia
Phase 4 · Status unknown · 1 trial
Ascites
Phase 4 · Status unknown · 1 trial
Asthma
Phase 4 · Terminated · 1 trial
Atherosclerosis
Phase 4 · Status unknown · 1 trial
Bacterial vaginosis
Phase 4 · Status unknown · 1 trial
Chronic bronchitis
Phase 4 · Completed · 1 trial

Stopped

NCT00190034 · Suspended · Acute kidney injury
opposite result
NCT00569465 · Terminated · Diabetes mellitus
End of the study
NCT04226456 · Terminated · Ototoxicity
poor recruitment
NCT00996424 · Terminated · Cystic Fibrosis
Insufficient recruitment.
NCT03581084 · Terminated · Asthma
The study was redesigned to be conducted in an outpatient setting.
NCT03680911 · Terminated · Anosmia
Poor participant compliance

All 15

NCT01424033 · Terminated · Diffuse Scleroderma
Departure of study team
NCT03391856 · Terminated · Thrombocytopenia
protocol changed
NCT03596125 · Terminated · Premature birth
difficulty of recruitment
NCT03423667 · Terminated · Cocaine-Related Disorders
Difficulties in recruitment (single addictions become rare)
NCT00539188 · Terminated · Self-Injurious Behavior
Study terminated due to poor subject compliance.
NCT01726465 · Terminated · Hepatocellular carcinoma
The first phase was completed
NCT04920448 · Terminated · Ischemic stroke
lack of patients
NCT02569957 · Terminated · Ovarian Neoplasms
The trial was halted prematurely due to slow accrual.
NCT00467831 · Terminated · Lung disease
insufficient enrollment