Transposable element activity
Pathway3 papers3 findingsGO 0032196
- Humans1
- Animals1
- Model organisms1
Interventions
1Social isolation
upin flies1
1 study
Social isolation
upin flies1
Social isolation activates transposable element activity in flies.
Model organismsTDP-43 induction
Early social isolation accelerates TDP-43 neurodegeneration and shortens lifespan in fruit flies · bioRxiv · 28 Sep 2026 · Preprint
Effects
1cGAS–STING signalling
upin reviews1
1 study
cGAS–STING signalling
upin reviews1
Transposable element activity activates cGAS–STING signalling.
Review
[Mechanisms of cGAS-STING-mediated chronic inflammation and targeted interventions in brain aging] · Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 1 Jul 2026
Upstream
1UHRF1
upin zebrafish1
1 study
UHRF1
upin zebrafish1
UHRF1 activates transposable element activity in zebrafish.
Animalsin zebrafish hepatocytes
UHRF1 levels drive distinct senescent states in zebrafish liver cells · EMBO reports · 28 Sep 2026
Latest
4Early social isolation accelerates TDP-43 neurodegeneration and shortens lifespan in fruit flies
Young flies housed alone showed faster retrovirus activation and more aggressive protein spread from glia to neurons.Young flies housed alone showed faster retrovirus activation and more aggressive protein spread from glia to neurons.
[Mechanisms of cGAS-STING-mediated chronic inflammation and targeted interventions in brain aging]
UHRF1 levels drive distinct senescent states in zebrafish liver cells
High UHRF1 expression causes stable senescence sensitive to Navitoclax, while cells with lower expression proliferate if tp53 is mutated.High UHRF1 expression causes stable senescence sensitive to Navitoclax, while cells with lower expression proliferate if tp53 is mutated.