Blood and immune system
Body system232 papersUBERON 0002390
- Human trial17
- Humans130
- Animals37
- Cells11
- In silico6
Latest
232Characterizing the B-cell senescence signature in driving the disease phenotype in COPD/emphysema
Direct conversion to neural stem cells de-ages human blood cells
Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process.Converted cells preserved around 13% and 5% of original donor age at low and high passages, respectively, through a protracted de-aging process.
Immunosenescence in tumor progression: from synergistic mechanisms to therapeutic strategies
Electronic frailty index predicts CAR-T outcomes in older adults
Very frail older patients had worse overall survival (HR=1.64) and event-free survival (HR=2.02) after CAR-T therapy than robust or prefrail peers.Very frail older patients had worse overall survival (HR=1.64) and event-free survival (HR=2.02) after CAR-T therapy than robust or prefrail peers.
Prostaglandin E2 drives cellular senescence and scar fibrosis after cesarean section in mice
Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean…Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean defects.
Rapamycin improves efferocytosis and reduces plaques in mice
In ApoE-/- mice, rapamycin reduced aortic lipid-positive area from 25.32 ± 0.98% to 12.28 ± 1.49% and increased plaque efferocytosis index from 0.36 ±…In ApoE-/- mice, rapamycin reduced aortic lipid-positive area from 25.32 ± 0.98% to 12.28 ± 1.49% and increased plaque efferocytosis index from 0.36 ± 0.02 to 1.37 ± 0.15.
Tool converts plasma pTau217 values across testing platforms
Assays predicted amyloid-beta positivity with AUCs of 0.929 to 0.952, while simulated pTau217 screening cut amyloid PET scans by over 60%.Assays predicted amyloid-beta positivity with AUCs of 0.929 to 0.952, while simulated pTau217 screening cut amyloid PET scans by over 60%.
High hemoglobin glycation index is linked to incident stroke
High glycation index was associated with increased stroke risk at an adjusted hazard ratio of 1.392, which remained 1.333 after HbA1c adjustment.High glycation index was associated with increased stroke risk at an adjusted hazard ratio of 1.392, which remained 1.333 after HbA1c adjustment.
Spinal bone marrow fat increases with age across all regions
In 81,318 UK Biobank adults, vertebral bone marrow fat rose 2.95% to 3.83% per decade across spinal regions, with higher levels in females.In 81,318 UK Biobank adults, vertebral bone marrow fat rose 2.95% to 3.83% per decade across spinal regions, with higher levels in females.
Plasma NfL rises up to 14.6 years before ALS diagnosis
In a nested case-control study, each standard deviation increase in plasma NfL was tied to 1.7-fold higher ALS odds 5 to 14.6 years before diagnosis.In a nested case-control study, each standard deviation increase in plasma NfL was tied to 1.7-fold higher ALS odds 5 to 14.6 years before diagnosis.
Summary-level genetic method improves Alzheimer's risk prediction
The endoPRS-SS framework boosted computational efficiency up to 90-fold while using summary statistics and multiple endophenotypes to improve…The endoPRS-SS framework boosted computational efficiency up to 90-fold while using summary statistics and multiple endophenotypes to improve Alzheimer's disease risk prediction.
Semaglutide may protect kidneys by reducing vascular resistance
In a 52-week trial of 106 people with type 2 diabetes and chronic kidney disease, semaglutide reduced renal vascular resistance without altering…In a 52-week trial of 106 people with type 2 diabetes and chronic kidney disease, semaglutide reduced renal vascular resistance without altering coprimary imaging endpoints.
An 11-protein blood score tracks incident dementia risk
In over 36,000 UK Biobank participants, the signature raised Harrell's C-index from 0.798 to 0.862, carrying a hazard ratio of 2.645 per standard…In over 36,000 UK Biobank participants, the signature raised Harrell's C-index from 0.798 to 0.862, carrying a hazard ratio of 2.645 per standard deviation increase.
Plasma p-tau217 yields discordant Alzheimer results in 8.5% of adults
False-negative blood results occurred in 5.6% of participants compared with false positives in 2.8%, with mismatches tied to kidney function, BMI, and…False-negative blood results occurred in 5.6% of participants compared with false positives in 2.8%, with mismatches tied to kidney function, BMI, and clinical stage.
Early life stress accelerates epigenetic aging in zebra finches
Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.
Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice
Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain…Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.
SATB1 loss reshapes 3D genome in mouse naive T cells
Diminished SATB1 in murine naive CD4⁺ T cells weakens TAD boundaries, rewires enhancer-promoter interactions, and increases proinflammatory gene…Diminished SATB1 in murine naive CD4⁺ T cells weakens TAD boundaries, rewires enhancer-promoter interactions, and increases proinflammatory gene expression during aging.