NAD+ & sirtuinsReview26 Sep 2026

SIRT1 in Senescence: Mitochondria and Immune Crosstalk

Biology

Abstract · CC BY

Cellular senescence is one of the hallmarks of aging. These growth-arrested cells actively secrete inflammatory mediators that reshape the tissue microenvironment and fuel age-related pathology.

The paper

Namkaew J, Kongpracha P, Mahawan T et al.

Biology · 8 Sep 2026

doi.org/10.3390/biology15181573 PubMed

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SIRT1 in Senescence: Mitochondria and Immune Crosstalk

The paper

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Macrophage CD38 drives age-related placental senescence by depleting NAD+

Activating Sirt1 reduces aortic valve calcification in mice and human cells

AMPK lengthens the circadian clock period through NAD+-dependent regulation of Bmal1

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