In normal-hearing listeners, auditory brainstem responses and behavioral detection thresholds revealed that declining Wave V amplitudes correlated…In normal-hearing listeners, auditory brainstem responses and behavioral detection thresholds revealed that declining Wave V amplitudes correlated with poorer temporal processing at higher sound levels.
Exposures to synthetic and ocean-derived micro- and nanoplastics activated senescence pathways and altered neuronal network activity in…Exposures to synthetic and ocean-derived micro- and nanoplastics activated senescence pathways and altered neuronal network activity in region-specific cortical organoids. In human cortical brain organoids, exposure to environmentally relevant micro- and nanoplastics triggers cellular…
Using human stem cell-derived macrophages, a preprint finds DNMT3A mutations derepress bivalent Polycomb target genes and enhance cell migration…Using human stem cell-derived macrophages, a preprint finds DNMT3A mutations derepress bivalent Polycomb target genes and enhance cell migration toward injured tissue. In isogenic human embryonic stem cell-derived macrophage models, researchers investigated how clonal hematopoiesis…
Mass spectrometry showed error frequencies increased in post-mitotic mouse tissues during aging but not in dividing cells, correlating with changes in…Mass spectrometry showed error frequencies increased in post-mitotic mouse tissues during aging but not in dividing cells, correlating with changes in tRNA pools. In a preprint study using yeast and mice, researchers tracked proteome-wide amino acid misincorporations using mass…
A preprint using transcriptomic, histological and ultrastructural analyses of killifish optic nerves shows aging brings reduced myelin thickness and…A preprint using transcriptomic, histological and ultrastructural analyses of killifish optic nerves shows aging brings reduced myelin thickness and immune-responsive glia. In killifish, the optic nerve displays hallmarks of mammalian white matter aging, according to a preprint analyzing…
In progeroid mice, activating the GPR81 receptor with the agonist CHBA reduced arterial lipid buildup, lowered cellular senescence, and improved…In progeroid mice, activating the GPR81 receptor with the agonist CHBA reduced arterial lipid buildup, lowered cellular senescence, and improved endothelial integrity. In human aortic transcriptomic data, expression of the lactate receptor gene HCAR1 declined significantly with age.
Inhibiting the fatty acid oxidation enzyme suppresses both autophagy and longevity in long-lived rsks-1 mutant Caenorhabditis elegans.Inhibiting the fatty acid oxidation enzyme suppresses both autophagy and longevity in long-lived rsks-1 mutant Caenorhabditis elegans. In Caenorhabditis elegans, researchers assessed reactive oxygen species levels across five long-lived mutant strains using four distinct probes.
In elderly COVID-19 patients, altered phospholipid and bile acid metabolites tracked with T-cell senescence, inflammatory cytokines, and 180-day…In elderly COVID-19 patients, altered phospholipid and bile acid metabolites tracked with T-cell senescence, inflammatory cytokines, and 180-day mortality. In elderly COVID-19 patients, plasma metabolomic profiles differed markedly from healthy controls and differed between survivors and…
Targeting ubiquinone biosynthesis counteracted reduced oxygen consumption and rescued lifespan loss caused by mitochondrial phosphatidylethanolamine…Targeting ubiquinone biosynthesis counteracted reduced oxygen consumption and rescued lifespan loss caused by mitochondrial phosphatidylethanolamine deficiency in Caenorhabditis elegans.
Inhibiting the proteasome accelerates ATP depletion, protein aggregation, and clearance markers in stored and aged red blood cells.Inhibiting the proteasome accelerates ATP depletion, protein aggregation, and clearance markers in stored and aged red blood cells. Researchers examined red blood cells in vitro to determine how proteasome inhibition affects cell quality during storage and physiological restoration.
Conditioned medium from damaged astrocytes alters extracellular mitochondria and triggers ATP depletion and oxidative stress in human postmitotic…Conditioned medium from damaged astrocytes alters extracellular mitochondria and triggers ATP depletion and oxidative stress in human postmitotic neurons. In cultured primary human astrocytes and human postmitotic neurons, researchers investigated how astrocyte senescence influences…
The loss of hepatic growth hormone signaling disrupts lipid metabolism and causes mitochondrial damage that can be counteracted by inhibiting PDK4.The loss of hepatic growth hormone signaling disrupts lipid metabolism and causes mitochondrial damage that can be counteracted by inhibiting PDK4. In a study of mice, researchers found that deleting the growth hormone receptor specifically in hepatocytes accelerated aging-related decline.
Aged mice on a high-fat diet and L-NAME showed impaired mitochondrial proteostasis rather than defective biogenesis, suggesting quality control may…Aged mice on a high-fat diet and L-NAME showed impaired mitochondrial proteostasis rather than defective biogenesis, suggesting quality control may contribute to reduced cardiac reserve.
Structural analyses of humans and mice reveal that fibers shrink primarily by shedding myofibrils rather than reducing myofibril size.Structural analyses of humans and mice reveal that fibers shrink primarily by shedding myofibrils rather than reducing myofibril size. In young and older humans and mice, researchers examined the macroscopic to ultrastructural drivers of skeletal muscle loss.
Mice lacking the receptor also showed higher inflammation, elevated DNA damage, and a five-month reduction in median lifespan.Mice lacking the receptor also showed higher inflammation, elevated DNA damage, and a five-month reduction in median lifespan. In a study of young and aged mice, researchers investigated how Type 2 Angiotensin II receptor (AT2R) deficiency affects cardiac aging.
Bulk RNA sequencing and co-culture assays revealed distinct transcriptional responses to aging and loss of synaptogenic function in specific…Bulk RNA sequencing and co-culture assays revealed distinct transcriptional responses to aging and loss of synaptogenic function in specific hippocampal astrocyte subpopulations.
A cross-species single-cell atlas links injured human kidney cells and aged mouse kidneys to shared chromatin reorganization and impaired repair.A cross-species single-cell atlas links injured human kidney cells and aged mouse kidneys to shared chromatin reorganization and impaired repair. Analyzing healthy and injured human kidneys alongside aged mouse kidneys, researchers created a cross-species single-cell multiomics atlas…
In Klotho-deficient mice, reduced SOX2 expression was linked to smaller taste buds, altered muscle structure, and lower levels of sensory neurotrophic…In Klotho-deficient mice, reduced SOX2 expression was linked to smaller taste buds, altered muscle structure, and lower levels of sensory neurotrophic factors. In Klotho-deficient mice, a model of accelerated aging, researchers examined structural and molecular shifts in the tongue…
Ear pinna fibroblasts from fetal, young, and old spiny mice maintained low-respiring, spherical mitochondria and stayed resistant to oxidative stress…Ear pinna fibroblasts from fetal, young, and old spiny mice maintained low-respiring, spherical mitochondria and stayed resistant to oxidative stress throughout the lifespan. In primary ear pinna fibroblasts isolated from spiny mice, rabbits, laboratory mice, and rats, researchers tested…
