Type I interferon signalling
Pathway8 papers3 findingsGO 0060337
- Humans1
- Animals2
- Model organisms1
- Cells1
Interventions
1L1HS overexpression
upin human cells1
1 study
L1HS overexpression
upin human cells1
L1HS overexpression induces type I interferon signalling in human cells.
Cellstransient overexpressionIMR-90
Acute LINE-1 transcription remodels the molecular landscape of human fibroblasts · bioRxiv : the preprint server for biology · 8 Sep 2026 · Preprint
Upstream
1Transposable elements
upin humans1
1 study
Transposable elements
upin humans1
transposable elements induce type I interferon signalling in humans.
Review
The regulatory and therapeutic potential of transposable elements in cancer and inflammatory diseases · Pharmacology & therapeutics · 25 Sep 2026
Associations
1Optic nerve
upin killifish1
1 study
Optic nerve
upin killifish1
Optic nerve is associated with type I interferon signalling in killifish.
Animalsduring agingoptic nerve
Interferon-responsive oligodendrocytes emerge during white matter aging in killifish · bioRxiv · 25 Sep 2026 · Preprint
Latest
8Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice
Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.
bioRxiv · R. Carvalho D et al.
Acute LINE-1 transcription remodels the molecular landscape of human fibroblasts
Transient overexpression of the retrotransposon alters gene expression, proteins, and secretions while affecting cell cycle and interferon pathways.
bioRxiv : the preprint server for biology · Bravo JI et al.
[Mechanisms of cGAS-STING-mediated chronic inflammation and targeted interventions in brain aging]
Persistent interferon-gamma fuels chronic cardiac remodeling after heart attacks in aged mice
A conserved interferon-gamma signature and heightened T cell recruitment drive worse long-term heart failure outcomes in older mice following myocardial infarction.
Journal of molecular and cellular cardiology · Melika ET et al.
Activin A from inflammatory macrophages impairs stem cell regulation in aging human muscle
Researchers mapped signaling pathways between senescent-like immune cells and muscle stem cells across multiple human transcriptomic datasets.
International journal of molecular sciences · Liu X et al.
Interferon-responsive oligodendrocytes emerge during white matter aging in killifish
The newly identified cellular state mirrors disease-associated glia in mammals and arises before overt signs of neurodegeneration appear.
bioRxiv · Serneels P et al.