Bones and joints
Body system131 papersUBERON 0001434
- Human trial8
- Humans68
- Animals13
- Model organisms1
- Cells3
- In silico3
Latest
131Treatment-dependent association between sarcopenia and ADL at discharge after osteoporotic vertebral fractures
Family-based transitional care for older adults after hip fracture surgery: a feasibility study
Calcium overload impairs muscle regeneration by driving sustained NFAT signaling
Inhibiting NFAT restored myoblast differentiation in culture and improved myofiber repair in injured mice.Inhibiting NFAT restored myoblast differentiation in culture and improved myofiber repair in injured mice.
Are we at risk of increasing sarcopenia? Implications for osteoarthritis and osteoporosis
Renal Function, Appendicular Lean Mass, and Bone Stiffness: Indirect Associations Through Fibroblast Growth Factor 21
Sex hormone-binding globulin raises lumbar fracture risk
Genetically higher SHBG increased lumbar fracture risk with an odds ratio of 1.201 in FinnGen and 1.005 in UK Biobank, mediated primarily by bone…Genetically higher SHBG increased lumbar fracture risk with an odds ratio of 1.201 in FinnGen and 1.005 in UK Biobank, mediated primarily by bone density.
Spinal bone marrow fat increases with age across all regions
In 81,318 UK Biobank adults, vertebral bone marrow fat rose 2.95% to 3.83% per decade across spinal regions, with higher levels in females.In 81,318 UK Biobank adults, vertebral bone marrow fat rose 2.95% to 3.83% per decade across spinal regions, with higher levels in females.
Age and frailty interaction models predict hip fracture mortality
Across 115,643 patients, predicted 30-day mortality ranged from 0.48% to 32.06% depending on age, frailty, and surgical fixation type.Across 115,643 patients, predicted 30-day mortality ranged from 0.48% to 32.06% depending on age, frailty, and surgical fixation type.
ARNI links to lower osteoporosis risk in heart failure
Patients taking an ARNI had an adjusted hazard ratio of 0.6 for osteoporosis compared with those taking an ACE inhibitor.Patients taking an ARNI had an adjusted hazard ratio of 0.6 for osteoporosis compared with those taking an ACE inhibitor.
Long spaceflights tied to higher hip fracture rates in astronauts
After missions over 90 days, astronauts had higher hip fracture rates resembling terrestrial peers 8 to 16.5 years older, with no difference at other…After missions over 90 days, astronauts had higher hip fracture rates resembling terrestrial peers 8 to 16.5 years older, with no difference at other skeletal sites.
CT biomarkers improve postoperative mortality prediction
Adding automated CT biomarkers to an ICD-based frailty score raised one-year mortality prediction AUROC from 0.75 to 0.79 in 7,638 surgery patients.Adding automated CT biomarkers to an ICD-based frailty score raised one-year mortality prediction AUROC from 0.75 to 0.79 in 7,638 surgery patients.
Human lymph node fibroblasts show cellular aging features before rheumatoid arthritis onset
Fibroblasts from individuals at risk for rheumatoid arthritis exhibit impaired adipogenic differentiation and downregulated DNA repair and cell cycle…Fibroblasts from individuals at risk for rheumatoid arthritis exhibit impaired adipogenic differentiation and downregulated DNA repair and cell cycle pathways.
Aging impairs tentacle regeneration in Cladonema medusae
Aged Cladonema medusae show stem cell depletion, increased DNA damage, delayed wound closure, and defective blastema formation during tentacle repair.Aged Cladonema medusae show stem cell depletion, increased DNA damage, delayed wound closure, and defective blastema formation during tentacle repair.