Ubiquitin–proteasome system

1. BAG3 knockout decreases ubiquitin–proteasome system in human cells.

   Cellsin BAG3-deficient astrocytesCRISPR/Cas9 editingastrocyte

   Astrocytic BAG3 regulates protein clearance systems linked to Alzheimer disease · Proceedings of the National Academy of Sciences of the United States of America · 28 Sep 2026

BAG3 knockout →

1. Fbxl21 mediates ubiquitin–proteasome system in mouse cells.

   Cells

   Circadian E3 ligase FBXL21 regulates daily muscle proteostasis by targeting DNAJB6 · EMBO reports · 30 Sep 2026

Fbxl21 →

1. SNCA impairs ubiquitin–proteasome system in humans.

   “pathogenic α-synuclein species interact with and impair 20S/26S proteasomes, affecting proteolytic activity, subunit composition, and complex assembly”

   Reviewpathogenic species

   Breaking the proteasome balance: α-synuclein and the ubiquitin-proteasome system · Frontiers in cell and developmental biology · 10 Sep 2026

SNCA →

1. Ubiquitin–proteasome system is associated with loss of proteostasis in silico.

   In silicoin AD brain transcriptomicsbrain

   A multi-region transcriptomic framework reveals global and region-specific ubiquitin-proteasome system biomarkers in Alzheimer's disease · Functional & integrative genomics · 29 Sep 2026

Loss of proteostasis →

1. Alzheimer's disease is associated with ubiquitin–proteasome system in silico.

   In silicoin vulnerable brain regionsbrain

   A multi-region transcriptomic framework reveals global and region-specific ubiquitin-proteasome system biomarkers in Alzheimer's disease · Functional & integrative genomics · 29 Sep 2026

Alzheimer's disease →