Resources: datasets, atlases and tools
Method24 papers
- Humans11
- Animals5
- Cells2
- In silico6
Latest
24Wearable movement data links to hundreds of human diseases
In 70,473 adults followed for up to 10 years, 210 wearable activity phenotypes were linked to 406 diseases, with step intensity and circadian rhythm…In 70,473 adults followed for up to 10 years, 210 wearable activity phenotypes were linked to 406 diseases, with step intensity and circadian rhythm showing prominent ties.
Spinal bone marrow fat increases with age across all regions
In 81,318 UK Biobank adults, vertebral bone marrow fat rose 2.95% to 3.83% per decade across spinal regions, with higher levels in females.In 81,318 UK Biobank adults, vertebral bone marrow fat rose 2.95% to 3.83% per decade across spinal regions, with higher levels in females.
Cognitive test battery validated in older adults in Lebanon
In a study of 3,027 older adults in Lebanon, an adapted cognitive protocol showed good model fit and trajectories aligned with age and education.In a study of 3,027 older adults in Lebanon, an adapted cognitive protocol showed good model fit and trajectories aligned with age and education.
App knock-in mice display age-dependent Alzheimer's pathology
In a study of App SAA knock-in mice from 4 to 19 months, animals developed progressive amyloid pathology, neuroinflammation, biomarker shifts, and…In a study of App SAA knock-in mice from 4 to 19 months, animals developed progressive amyloid pathology, neuroinflammation, biomarker shifts, and synaptic loss.
Automated tool counts teeth from routine brain MRI
The model counted teeth with a mean absolute error of 1.96 and matched manual associations with cognitive scores in a 233-person cohort.The model counted teeth with a mean absolute error of 1.96 and matched manual associations with cognitive scores in a 233-person cohort.
Video-derived balance score tracks age and fall risk
Tested in 180 participants, the StaBLE score correlated strongly with age (ρ = -0.76) and separated individuals at risk of falling from those who were…Tested in 180 participants, the StaBLE score correlated strongly with age (ρ = -0.76) and separated individuals at risk of falling from those who were not.
Dietary restriction activates autophagy through selective oxidation of ATG5
Reversible oxidation of a single cysteine residue enables core autophagosome formation and prevents severe tissue pathology during nutrient limitation…Reversible oxidation of a single cysteine residue enables core autophagosome formation and prevents severe tissue pathology during nutrient limitation in mice.
Long read sequencing of retinal RNA improves killifish transcriptome annotation
Chemogenetic hydrogen sulfide production reverses vascular remodeling in aged mice
Targeting hydrogen sulfide generation to endothelial mitochondria mitigated senescence programs and reversed vascular remodeling in aged mice.Targeting hydrogen sulfide generation to endothelial mitochondria mitigated senescence programs and reversed vascular remodeling in aged mice.
Human vellus hair units undergo cellular and metabolic remodeling during skin aging
A single-nucleus atlas reveals stem cell loss, altered sebocyte activity, and shifted immune interactions in the hair follicles of older men.A single-nucleus atlas reveals stem cell loss, altered sebocyte activity, and shifted immune interactions in the hair follicles of older men.
Aging alters neutrophil states across multiple organs in mice
Single-cell profiling of young and aged mice revealed organ-specific neutrophil remodeling, showing subsets enriched for inflammatory and IL-6…Single-cell profiling of young and aged mice revealed organ-specific neutrophil remodeling, showing subsets enriched for inflammatory and IL-6 pathways that induced senescence-linked responses in vitro.
Single-cell foundation models show task-dependent utility for aging biology research
A benchmark across 2.5 million single-cell transcriptomes reveals strengths in detecting rare cell states and gene networks, though simple gene sets…A benchmark across 2.5 million single-cell transcriptomes reveals strengths in detecting rare cell states and gene networks, though simple gene sets predicted age better.
Partial Y chromosome loss alters transcription in cancer cells
Using genomic and transcriptomic profiling in male cancer cell lines, researchers mapped regional deletions and linked a new Y erosion score to…Using genomic and transcriptomic profiling in male cancer cell lines, researchers mapped regional deletions and linked a new Y erosion score to transcriptional changes.
Practical considerations for characterization of the external exposome in Alzheimer's disease and related dementias cohorts
Genetic scores add more predictive power at lower clinical risk
For atherosclerotic cardiovascular disease, polygenic risk expanded the clinically identified high-risk subgroup by 40%, revealing patients with…For atherosclerotic cardiovascular disease, polygenic risk expanded the clinically identified high-risk subgroup by 40%, revealing patients with 4.9-fold higher incidence than those remaining low-risk.