mTOR & rapamycinAnimals
mTORC1-TFEB/TFE3 signaling is associated with bile acid diversification during hepatic metabolic adaptation
Science Advances
Abstract
The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal cues to regulate hepatic lipid metabolism with major implications for metabolic dysfunction-associated steatotic liver disease (MASLD).
- Protein restriction
- Rapamycin
- TFE3
- Lipid and ceramide metabolism
- Metabolic dysfunction-associated steatotic liver disease
- Humans
The paper
Alex Zaufel, Wenfei Sun, Nunzia Pastore, Tarek Moustafa
Show 24 more authors
Ulrike Taschler, Carina Wagner, Hubert Hackl, Judith Sommer, Dagmar Silbert-Wagner, Jan G. Hengsler, Brigitte Begher‐Tibbe, Rudolf E Stauber, Kolb Dagmar, Martin Trötzmüller, Benjamin Gottschalk, Chelsea L. Thorsheim, Eva-Lena Stange, Mathias Walter Hornef, Olga Pivovarova‐Ramich, Andreas F. H. Pfeiffer, Kylie P. Matchett, Anne Loft, Stephan Herzig, Neil Cowan Henderson, Andrea Ballabio, Zoltan Pierre Arany, Christian Wolfrum, Peter Fickert,Medical University of Graz
Science Advances · 25 Sep 2026 · CC BY
