APOE
Gene4 papers1 findingHGNC 613MGI 88057NCBI Gene 348Taxon 9606
- Animals3
- Model organisms1
Effects
1Retinal degeneration
downin mice1
1 study
Retinal degeneration
downin mice1
APOE protects against retinal degeneration in mice.
Animalsvia oxidized lipid cargo disposal to subretinal microglianeural retina
Lack of dietary DHA drives harmful lipid remodeling and retinal degeneration in mice · bioRxiv · 28 Sep 2026 · Preprint
Latest
4Rapamycin reduces ferroptotic stress and shrinks atherosclerotic plaques in mice
The mTOR inhibitor restored macrophage efferocytosis and mitochondrial function while lowering aortic lipid burden in high-fat-fed ApoE-deficient…The mTOR inhibitor restored macrophage efferocytosis and mitochondrial function while lowering aortic lipid burden in high-fat-fed ApoE-deficient mice.
Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants
Lack of dietary DHA drives harmful lipid remodeling and retinal degeneration in mice
Restoring the fatty acid reversed visual decline in mice and cleared toxic oxidized lipids that otherwise trigger chronic microglial activation.Restoring the fatty acid reversed visual decline in mice and cleared toxic oxidized lipids that otherwise trigger chronic microglial activation.
Salvianolic acid A eases atherosclerosis in mice by eliminating senescent vascular cells
The compound disrupts an HSP90α complex to trigger endoplasmic reticulum stress and selectively induce apoptosis in senescent smooth muscle cells.The compound disrupts an HSP90α complex to trigger endoplasmic reticulum stress and selectively induce apoptosis in senescent smooth muscle cells.