Chromatin and 3D genome organisation
Pathway8 papers2 findingsGO 0006325
- Humans3
- Animals2
- Cells2
- In silico1
Upstream
1SATB1
downin mice1
1 study
SATB1
downin mice1
SATB1 protects against chromatin and 3D genome organisation in mice.
Animalsshown by conditional deletion in naive T cellsnaive CD4+ T cells
Loss of SATB1 alters 3D genome architecture in aged mouse T cells · Science advances · 2 Oct 2026
Associations
1Biological age
upin mice1
1 study
Biological age
upin mice1
Chromatin and 3D genome organisation predicts biological age in mice.
“identifying chromatin entropy, peripheral heterochromatin, and chromatin condensates as predictive markers.”
Animalshematopoietic stem cell
Deep learning predicts mouse hematopoietic stem cell aging from chromatin architecture · Aging cell · 28 Sep 2026
Latest
8Estrogen alters breast cancer risk variants in human DNA
Screening 1,604 variants identified 73 estrogen-responsive variants that interacted with age at first birth in 13,026 post-menopausal breast cancer…Screening 1,604 variants identified 73 estrogen-responsive variants that interacted with age at first birth in 13,026 post-menopausal breast cancer cases and 108,265 controls.
Transitional senescent monocytes drive age-related inflammation in humans
Researchers identified a transient senescent-like monocyte state governed by the transcription factor AP-1 that primes cells toward inflammatory and…Researchers identified a transient senescent-like monocyte state governed by the transcription factor AP-1 that primes cells toward inflammatory and sepsis-associated states.
Loss of SATB1 alters 3D genome architecture in aged mouse T cells
Declining levels of the chromatin organizer SATB1 disrupt genomic boundaries and drive inflammatory gene activation in naive CD4+ T cells.Declining levels of the chromatin organizer SATB1 disrupt genomic boundaries and drive inflammatory gene activation in naive CD4+ T cells.
Mammalian cellular identity erodes with age through predictable chromatin drift
Imperfect maintenance of developmental chromatin constraints causes age-associated DNA methylation gains predominantly at polycomb-regulated genomic…Imperfect maintenance of developmental chromatin constraints causes age-associated DNA methylation gains predominantly at polycomb-regulated genomic regions across mammalian tissues.
Restoring HIRA chromatin maintenance improves aged mouse oocyte quality
Preventing HIRA SUMOylation rescues histone replacement, restoring chromatin integrity and developmental potential in aging mouse eggs.Preventing HIRA SUMOylation rescues histone replacement, restoring chromatin integrity and developmental potential in aging mouse eggs.
Deep learning predicts mouse hematopoietic stem cell aging from chromatin architecture
A convolutional neural network named ChromAgeNet distinguished young from aged mouse stem cells using three-dimensional nuclear images and identified…A convolutional neural network named ChromAgeNet distinguished young from aged mouse stem cells using three-dimensional nuclear images and identified key structural markers of aging.
DNMT3A mutations linked to clonal hematopoiesis alter macrophage epigenetics and accelerate migration
The mutations derepress Polycomb target genes at specific chromatin sites and prompt earlier macrophage recruitment to injured tissues.The mutations derepress Polycomb target genes at specific chromatin sites and prompt earlier macrophage recruitment to injured tissues.
Kidney tubular epithelial cells drive accelerated epigenetic aging in disease
A cross-species single-cell atlas links injured human kidney cells and aged mouse kidneys to shared chromatin reorganization and impaired repair.A cross-species single-cell atlas links injured human kidney cells and aged mouse kidneys to shared chromatin reorganization and impaired repair.