Fatty acid β-oxidation
Pathway9 papers2 findingsGO 0006635
- Humans2
- Animals3
- Model organisms3
Upstream
2Older age
upin humans1
1 study
Older age
upin humans1
Older age increases fatty acid β-oxidation in humans.
Humansover 24 hr
Age-Related Differences in Carbohydrate and Fat Oxidation Over 24 Hours and During Daily Activities in Humans · bioRxiv · 29 Sep 2026 · Preprint
rsks-1
upin worms1
1 study
rsks-1
upin worms1
rsks-1 increases fatty acid β-oxidation in worms.
“transcriptomic analysis revealed that the genes involved in peroxisomal fatty acid β-oxidation were upregulated in the rsks-1(ok1255) mutants.”
Model organismsrsks-1(ok1255) mutants
Peroxisomal enzyme ACOX-1.2 enables extended lifespan in long-lived roundworms · Current issues in molecular biology · 4 Sep 2026
Latest
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Loss of the lipid enzyme PNPLA7 impairs skeletal muscle and mitochondria in mice
Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and…Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance.
4-Octyl itaconate restores parotid gland function in aging mice
The itaconate derivative reduces fibrosis and lipid buildup while curbing oxidative stress through AMPK signaling pathways.The itaconate derivative reduces fibrosis and lipid buildup while curbing oxidative stress through AMPK signaling pathways.
Effect of FATmax-Intensity Exercise on Body Composition and Cardiovascular Health in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis
Lactate receptor activation reduces cellular senescence and protects vascular health in mice
Loss of the lactate receptor GPR81 drives arterial senescence and lipid accumulation, while pharmacological stimulation restores vascular homeostasis…Loss of the lactate receptor GPR81 drives arterial senescence and lipid accumulation, while pharmacological stimulation restores vascular homeostasis in progeroid mice.
Peroxisomal enzyme ACOX-1.2 enables extended lifespan in long-lived roundworms
Inhibiting the fatty acid oxidation enzyme suppresses both autophagy and longevity in long-lived rsks-1 mutant Caenorhabditis elegans.Inhibiting the fatty acid oxidation enzyme suppresses both autophagy and longevity in long-lived rsks-1 mutant Caenorhabditis elegans.
Plasma metabolic shifts link to T-cell senescence and mortality in older COVID-19 patients
Dysregulated phospholipid and bile acid metabolism tracked with cytokine spikes and 180-day mortality, while a specific lipid attenuated senescent…Dysregulated phospholipid and bile acid metabolism tracked with cytokine spikes and 180-day mortality, while a specific lipid attenuated senescent markers in cell tests.