Whole-cell recordings in adult and aged humanized mice showed that APOE4 modified pyramidal cell and interneuron properties depending on both age and…Whole-cell recordings in adult and aged humanized mice showed that APOE4 modified pyramidal cell and interneuron properties depending on both age and sex. In adult and aged humanized APOE3 and APOE4 knock-in mice of both sexes, researchers examined structural, intrinsic, and synaptic…
Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development. In a new preprint, researchers engineered mice to confine mitochondrial DNA mutagenesis to specific developmental windows.
In mice infected with influenza, CD8+ T cells lacking one TFAM copy provoked lung immunopathology without improving viral control and later lost…In mice infected with influenza, CD8+ T cells lacking one TFAM copy provoked lung immunopathology without improving viral control and later lost recall immunity. In human CD8+ T cells, researchers observed an age-associated decline in TFAM expression and mitochondrial function, according…
Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical…Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical cardiomyocyte hypertrophy. In the African turquoise killifish (Nothobranchius furzeri), researchers characterized age-related cardiac remodeling using…
Left parietal-putamen connectivity predicted better cognitive flexibility in young adults (r = 0.41) but worse performance in older adults (r =…Left parietal-putamen connectivity predicted better cognitive flexibility in young adults (r = 0.41) but worse performance in older adults (r = -0.33). In a cross-sectional study of 40 younger (ages 18–35) and 40 older healthy adults (ages 60–85), researchers tracked how brain…
In older adults, higher autophagy flux in blood cells linked to lower physical function and decreased after a 12-week exercise intervention.In older adults, higher autophagy flux in blood cells linked to lower physical function and decreased after a 12-week exercise intervention. Researchers analyzed transcriptomics and autophagic flux across matched human cells, including primary fibroblasts, induced neurons, and peripheral…
Growth hormone treatment rescues germline redox balance and sperm quality in aged males through a Grtp1-dependent mechanism.Growth hormone treatment rescues germline redox balance and sperm quality in aged males through a Grtp1-dependent mechanism. In an animal study of reproductive aging, researchers used single-cell transcriptomics and cross-sex comparisons to identify Grtp1 as a key protector of male…
In 40 older and 37 younger adults tested with magnetoencephalography, aging amplified early sensory deviance responses but attenuated later cognitive…In 40 older and 37 younger adults tested with magnetoencephalography, aging amplified early sensory deviance responses but attenuated later cognitive network activity. In 40 older adults aged 60 to 81 and 37 younger adults aged 18 to 25, researchers mapped whole-brain activity using…
Exposure to environmental arsenic caused heart dysfunction via the p53 and p21 pathway, which quercetin treatment reversed in cultured rat…Exposure to environmental arsenic caused heart dysfunction via the p53 and p21 pathway, which quercetin treatment reversed in cultured rat cardiomyoblasts. In male C57BL/6 mice and rat cardiomyoblasts, researchers examined how environmental arsenic promotes cardiac aging and whether…
Increasing histone 3 lysine 9 methylation reduced leukemogenesis in both young and aged murine cells.Increasing histone 3 lysine 9 methylation reduced leukemogenesis in both young and aged murine cells. In experiments using mice, murine hematopoietic stem and progenitor cells, human cell lines, and patient samples, researchers tested how histone 3 lysine 9 (H3K9) methylation influences…
Transcriptomic profiling of human skeletal muscle paired with cell experiments identified inflammatory macrophages and Activin A signaling as…Transcriptomic profiling of human skeletal muscle paired with cell experiments identified inflammatory macrophages and Activin A signaling as candidate regulators of altered muscle stem cells.
