Epigenetic clock
Biomarker6 papers2 findings
- Humans2
- Model organisms1
- In silico1
Associations
2Schizophrenia
upin humans1
1 study
Schizophrenia
upin humans1
Schizophrenia is associated with epigenetic clock in humans.
Humansin patients with glymphatic impairment
Impaired glymphatic clearance links inflammation to accelerated brain aging in schizophrenia · bioRxiv · 30 Sep 2026 · Preprint
Stress
upin humans1
1 study
Stress
upin humans1
Stress is associated with epigenetic clock in humans.
Reviewin second- and third-generation clocks
A Conceptual Framework for Understanding the Effects of Stress on Epigenetic Aging · Annual review of psychology · 29 Sep 2026
Latest
14Early life stress accelerates epigenetic aging in zebra finches
Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.
bioRxiv · Olova NN et al.
Proteomic organ clocks predict mortality but trail established physiological and epigenetic biomarkers
In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.
Aging cell · Pyrgioti M et al.
Blood cell composition explains substantial variation in DNA methylation age
Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.
Genome medicine · Jonkman TH et al.
Epigenetic puberty index tracks biological aging and adult health risks
A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts.
medRxiv · Wu Q et al.
Impaired glymphatic clearance links inflammation to accelerated brain aging in schizophrenia
Neuroimaging and post-mortem transcriptomics connect disrupted astrocytic aquaporin-4 polarization and blood-brain barrier breakdown to increased epigenetic and brain age.
bioRxiv · Tan X et al.
Mammalian cellular identity erodes with age through predictable chromatin drift
Imperfect maintenance of developmental chromatin constraints causes age-associated DNA methylation gains predominantly at polycomb-regulated genomic regions across mammalian tissues.
Nature · Yücel AD et al.
Exercise slows epigenetic aging in breast cancer survivors
A randomized trial shows a 12-month workout program slowed DNA methylation clocks and linked with preserved cognitive health.
Journal of the National Cancer Institute · Carlin D et al.
A Conceptual Framework for Understanding the Effects of Stress on Epigenetic Aging
Older adults with preserved cognition show slower biological aging and longer telomeres
An observational study in Chile linked perfect Mini-Mental State Examination scores in people over 80 to slower epigenetic clocks and longer estimated telomeres.
Aging and disease · Salech F et al.