ATG5
Gene1 paper3 findingsHGNC 589MGI 1277186NCBI Gene 9474Taxon 9606
- Animals1
Effects
2Autophagy
is required forin human cells1is required forin mice1
1 study
Autophagy
is required forin human cells1is required forin mice1
ATG5 is required for autophagy in mice.
Animalsupon nutrient restriction, via Cys19 oxidation
Dietary restriction activates autophagy through selective oxidation of ATG5 · bioRxiv : the preprint server for biology · 24 Sep 2026 · Preprint
ATG5 is required for autophagy in human cells.
Cellsupon nutrient restriction, via Cys19 oxidation
Dietary restriction activates autophagy through selective oxidation of ATG5 · bioRxiv : the preprint server for biology · 24 Sep 2026 · Preprint
Mortality
downin mice1
1 study
Mortality
downin mice1
ATG5 prevents mortality in mice.
Animalsduring nutrient restriction via Cys19 redox switch
Dietary restriction activates autophagy through selective oxidation of ATG5 · bioRxiv : the preprint server for biology · 24 Sep 2026 · Preprint
Latest
1Dietary restriction activates autophagy through selective oxidation of ATG5
Reversible oxidation of a single cysteine residue enables core autophagosome formation and prevents severe tissue pathology during nutrient limitation…Reversible oxidation of a single cysteine residue enables core autophagosome formation and prevents severe tissue pathology during nutrient limitation in mice.