SIRT6

Gene5 papers1 findingHGNC 14934NCBI Gene 51548Taxon 9606

Humans1
Animals2
Cells1
In silico1

Effects

1

Biological age

downin mice1

1 study

SIRT6 decreases biological age in mice.
Animalsoverexpression in mouse liverliver
Cell type-resolved chromatin accessibility clocks for brain aging · bioRxiv · 25 Aug 2026 · Preprint

Biological age →

Funding

National Institute on AgingUS$693kNational Eye InstituteUS$541.9k2 grants since 2014

Anti-Aging Molecule Sirt6 in Neuroprotection in Diabetic Retina
National Eye InstituteUniversity of Texas Med Br GalvestonUS$541.9k2023–2028
Regulation of epigenome stability by SIRT6 during Aging
National Institute on AgingUniversity of RochesterUS$693k2014–2029

Latest

5

Arthritis & RheumatologyAnimals22 Sep

MDL-800-induced SIRT6 activation decreases age-associated osteoarthritis in mice

bioRxivIn silicoPreprint7 Sep

A systematic evaluation of SIRT6 as transcriptomic biomarker of aging

Research SquareCellsPreprint30 Aug

Nicotinamide Mononucleotide Restores Pancreatic β-Cell Function in Type 2 Diabetes through SIRT6-HIF-1α-Mediated Mitochondrial Stress Adaptation and Glycolytic Reprogramming

Type 2 diabetes

Chemico-biological InteractionsAnimals28 Aug

SIRT6/RXRα/retinoic acid-related signaling contributes to intestinal stem cell homeostasis during aging and is modulated by Atractylenolide II

Gut and microbiome

bioRxivHumansPreprint25 Aug

Cell type-resolved chromatin accessibility clocks for brain aging