Intervertebral disc degeneration
Disease4 papers2 findingsMeSH D055959
- Animals2
- Cells2
Interventions
2Zinc
downin animals1
1 study
Zinc
downin animals1
Zinc decreases intervertebral disc degeneration.
“Consistently, dietary zinc supplementation effectively slows IVDD progression, highlighting a potential therapeutic strategy.”
Animals
Zinc influx promotes mitophagy to slow intervertebral disc degeneration · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026
Ergothioneine-derived carbon dots
downin animals1
1 study
Ergothioneine-derived carbon dots
downin animals1
Ergothioneine-derived carbon dots decrease intervertebral disc degeneration.
“Local EGT-Fe-CDs treatment also reduced degeneration in the animal model, based on imaging, disc height index (DHI), and Pfirrmann grade.”
Animalslocal EGT-Fe-CDs treatmentintervertebral disc
Ergothioneine carbon dot nanozymes reduce intervertebral disc degeneration in an animal model · Antioxidants (Basel, Switzerland) · 28 Aug 2026
Latest
4D-allose attenuates intervertebral disc degeneration by targeting a mitochondrial stress pathway
The rare sugar enhances mitophagy, blocks cGAS-STING signaling, and protects nucleus pulposus cells from senescence and apoptosis.
Experimental & molecular medicine · Zhao Z et al.
Mechanism of the NAMPT-SIRT2-Lactate Axis in Senescence of Human Nucleus Pulposus Cells
Zinc influx promotes mitophagy to slow intervertebral disc degeneration
Targeting the zinc transporter ZIP14 and ANXA2 deacetylation restores autophagic flux and limits degenerative spinal disease in experimental models.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Jin Y et al.
Ergothioneine carbon dot nanozymes reduce intervertebral disc degeneration in an animal model
The antioxidant nanozymes scavenged reactive oxygen species and reduced mitochondrial damage to protect nucleus pulposus cells.
Antioxidants (Basel, Switzerland) · Zhang Z et al.