Triglyceride
Biomarker1 paper
- Model organisms1
Latest
5Suppressing neuronal dENL/AF9 shifts metabolic and energetic profiles in aged flies
Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.
Neuropeptide signaling drives lipid breakdown during dietary restriction in roundworms
A relay involving sensory neurons, interneurons, and gut receptors coordinates fat mobilization when food intake drops.
Model organismsBrain aging
Alpha-synuclein impairs triglyceride metabolism and mitochondrial structure in aging nematodes
Restoring lipid balance through medium-chain triglycerides or fatty acid inhibition protected worms from alpha-synuclein-driven movement deficits.
HumansInflammaging
High metabolic inflammation trajectories predict faster frailty progression in older adults
Tracking the combined C-reactive protein-triglyceride-glucose index over time identified older adults at greater risk of incident frailty in two national cohorts.
Animals
Activating soluble guanylate cyclase restores amyloid-beta and LDL clearance in aged rats
Cinaciguat reversed endothelial defenestration and restored paracrine signaling that enables rat hepatocytes to clear circulating lipids and amyloid-beta.