Age-related hearing loss
Disease3 papers2 findings
- Humans1
- Animals1
Associations
2Mitochondrial dysfunction
upin reviews1
1 study
Mitochondrial dysfunction
upin reviews1
Mitochondrial dysfunction is associated with age-related hearing loss.
Reviewcochlea
Therapeutic Timing at Mitochondrial Redox-Autophagy-Mitophagy Checkpoints in Age-Related Hearing Loss · Molecular neurobiology · 30 Sep 2026
Igf1
downin mice1
1 study
Igf1
downin mice1
Igf1 is associated with age-related hearing loss in mice.
“Transcriptomics revealed significant downregulation of Igf1 and Slc25a33 in aged pericytes, with enrichment of the TGF-β signaling pathway.”
Animalspericyte
IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice · Aging cell · 30 Sep 2026
Latest
4Auditory nerve myelin degeneration defines a subtype of age-related hearing loss
Researchers linked poor auditory nerve synchrony and myelin degradation to amplified communication difficulties in older humans, beyond standard hearing thresholds.
medRxiv : the preprint server for health sciences · Harris KC et al.
Gut microbes from hearing loss patients trigger inner ear damage in young mice
Fecal transplants from elderly hearing loss patients induced blood-labyrinth barrier breakdown, neuroinflammation, and hair cell loss in recipient mice.
Research Square · Liu Y et al.
Therapeutic Timing at Mitochondrial Redox-Autophagy-Mitophagy Checkpoints in Age-Related Hearing Loss
IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice
Targeting this pathway curbs mitochondrial oxidative stress and pericyte activation to partially restore auditory function in mouse models.
Aging cell · Xu R et al.