WDR41

1. WDR41 is required for insulin sensitivity in mice.

   “WDR41, and WDR41 K319 lactylation, is essential for exercise-induced improvements in insulin sensitivity and lipid metabolism against excess lipid accumulation in the liver”

   Animalsshown by WDR41 depletion and WDR41K319R mutant

   Exercise-Induced Lactylation of WDR41 Initiates Autophagy and Improves MASLD

   ADA Scientific Sessions 2025 abstract·13 Jun 2025

1. WDR41 activates autophagy in mice.

   “lactylated WDR41 promotes autophagy initiation by directly binding to the autophagy proteins ATG13 and FIP200 and driving the ULK1 kinase complex assembly”

   Animalsexercise

   Exercise-Induced Lactylation of WDR41 Initiates Autophagy and Improves MASLD

   ADA Scientific Sessions 2025 abstract·13 Jun 2025

More on Autophagy

1. WDR41 is associated with lactylated WDR41 in humans.

   “A negative correlation between expression and lactylation of WDR41 was also discovered in patients with various hepatic metabolic dysfunctions”

   Humansliver

   Exercise-Induced Lactylation of WDR41 Initiates Autophagy and Improves MASLD

   ADA Scientific Sessions 2025 abstract·13 Jun 2025

More on Lactylated WDR41