Spermidine
InterventionPhase 33 papers2 findingsPubChem 1102ChEBI 16610MeSH D013095
- Animals1
- Cells1
Outcomes
2Endothelial function
upin mice1Very low certainty
1 study
Endothelial function
upin mice1Very low certainty
Spermidine improves endothelial function in mice.
Animalsin aldosterone-treated mice
Genetic and pharmacologic activation of BECLIN1 prevents aldosterone-induced cardiovascular damage · Clinical science (London, England : 1979) · 7 Sep 2026
Lifespan
downin yeast1
1 study
Lifespan
downin yeast1
Spermidine shortens lifespan in yeast.
“spermidine was not only unable to extend lifespan in rho0 yeast, but actually shortened lifespan.”
Reviewin mtDNA-deficient (rho0) yeast
INTERACTION OF SPERMIDINE AND A LOW-METHIONINE DIET ON LIFESPAN IN MTDNA-DEFICIENT SACCHAROMYCES CEREVISIAE · GSA 2024 abstract · 31 Dec 2024
Trials
5In trials
Phase 3 · Status unknown · 1 trial
No phase · Recruiting · 1 trial
Trial sponsors
Company1 trial70 people
1 trialPhase 346 people
1 trialPhase 1/258 people
Icahn School of Medicine at Mount Sinai
1 trialPhase 120 people
Universitätsmedizin Greifswald
1 trial76 people