Cardiovascular disease
Disease10 papers4 findingsMeSH D002318
In humans, retinal age gap is associated with cardiovascular disease, while reviews link clonal haematopoiesis and male loss of chromosome Y to the condition. Additionally, reviews note that omega-3 fatty acids show no effect in clinical trials.
- Humans1
Interventions
1Omega-3 fatty acids
no changein humans1
1 study
Omega-3 fatty acids
no changein humans1
Omega-3 fatty acids have no effect on cardiovascular disease in humans.
“The VITAL and STRENGTH trials failed to demonstrate significant cardiovascular benefit with omega-3 supplementation”
Reviewin the VITAL and STRENGTH trials
Oxidative Stress in Vascular Aging: Therapeutic Potential of the Antioxidant Paradox. A State-of-the-Art Review · Antioxidants (Basel, Switzerland) · 10 Sep 2026
Associations
3Clonal hematopoiesis
upin humans1
1 study
Clonal hematopoiesis
upin humans1
Clonal hematopoiesis is associated with cardiovascular disease in humans.
Review
Telomeres in Aging: Links to Clonal Hematopoiesis, Cardiovascular Disease, and Cancer · The American journal of medicine · 29 Sep 2026
Loss of chromosome Y
upin humans1
1 study
Loss of chromosome Y
upin humans1
Loss of chromosome Y is associated with cardiovascular disease in humans.
Reviewbloodmales
Mosaic Loss of Chromosome Y (LOY): From Genomic Instability to Disease and Single-Cell Detection · Frontiers in bioscience (Landmark edition) · 1 Sep 2026
Retinal age gap
upin humans1
1 study
Retinal age gap
upin humans1
Retinal age gap is associated with cardiovascular disease in humans.
“The resulting retinal age gap, i.e. the difference between predicted and chronological age, is associated with cardiometabolic traits, inflammation, cognitive performance, all-cause mortality, dementia, cancer, and incident cardiovascular disease.”
Humansretinan = 71,343
Retinal imaging model predicts age and reveals sex differences in human aging · Nature communications · 26 Aug 2026
Latest
18Aged perivascular fat increases aortic stiffness and collagen deposition in mice
Removing surrounding adipose tissue reduced stiffness in aged mouse aortas, pointing to fat fibrosis as a contributor to arterial stiffening.
American journal of physiology. Regulatory, integrative and comparative physiology · Buckley DJ et al.
Mosaic Loss of the Y Chromosome: Mechanisms and Diseases
Mosaic Loss of Chromosome Y (LOY): From Genomic Instability to Disease and Single-Cell Detection
Telomeres in Aging: Links to Clonal Hematopoiesis, Cardiovascular Disease, and Cancer
Traditional Chinese Medicine Formulas in Delaying Aging: From Theoretical Foundations to Molecular Mechanisms and Translational Perspectives
Persistent interferon-gamma fuels chronic cardiac remodeling after heart attacks in aged mice
A conserved interferon-gamma signature and heightened T cell recruitment drive worse long-term heart failure outcomes in older mice following myocardial infarction.
Journal of molecular and cellular cardiology · Melika ET et al.
Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance
The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · Chen X et al.
Lactate receptor activation reduces cellular senescence and protects vascular health in mice
Loss of the lactate receptor GPR81 drives arterial senescence and lipid accumulation, while pharmacological stimulation restores vascular homeostasis in progeroid mice.
bioRxiv · Wu Y et al.