Osteoarthritis

1. Osteoarthritis impairs mesenchymal stem cell.

   Review

   Clinical Translation of Mesenchymal Stem Cells to Medicinal Signaling Cells: Origins, Clinical Applications, and the Future of Regenerative Medicine-2026 Arnold I. Caplan Award for Distinguished Research in Orthobiologics · The Journal of the American Academy of Orthopaedic Surgeons · 30 Sep 2026

1. Lipid and ceramide metabolism induces osteoarthritis.

   Reviewfor certain cholesterol and fatty acid pathwaysjoint

   Lipid Networks in Osteoarthritis: Context-Dependent Drivers, Hallmarks of Aging, and Clinical Translation · Aging and disease · 23 Sep 2026

Lipid and ceramide metabolism →

1. Osteoarthritis is associated with mtDNA copy number in human cells.

   “OA-derived MSCs exhibited a markedly increased heteroplasmic burden, followed by decrease in mtDNA copy number”

   Cellsbone marrow mesenchymal stem cell

   Characterization of the Mitochondrial Genome Landscape in MSCs, iPSCs and iMSCs from Osteoarthritis Patients and Healthy Donors · Genes · 11 Sep 2026

mtDNA copy number →

1. Osteoarthritis is associated with mtDNA heteroplasmy in human cells.

   “OA-derived MSCs exhibited a markedly increased heteroplasmic burden, followed by decrease in mtDNA copy number and accumulation of non-synonymous variants”

   Cellsbone marrow mesenchymal stem cell

   Characterization of the Mitochondrial Genome Landscape in MSCs, iPSCs and iMSCs from Osteoarthritis Patients and Healthy Donors · Genes · 11 Sep 2026

mtDNA heteroplasmy →

1. Osteoarthritis is associated with WEE1 in silico (AUC 0.792).

   “CDKN1A, CDK6, and WEE1 were reduced in OA-associated meniscal samples in GSE98918; within-dataset ROC analyses yielded AUCs of 0.931, 0.882, and 0.792, respectively.”

   In silicomeniscus

   Senescence-Associated Checkpoint Gene Dysregulation in Established Osteoarthritis: Integrated Transcriptomic Analysis and In Vitro Evaluation of CDK6 and WEE1 · Biomedicines · 26 Aug 2026

WEE1 →

1. Osteoarthritis is associated with CDK6 in silico (AUC 0.882).

   “CDKN1A, CDK6, and WEE1 were reduced in OA-associated meniscal samples in GSE98918; within-dataset ROC analyses yielded AUCs of 0.931, 0.882, and 0.792, respectively.”

   In silicomeniscus

   Senescence-Associated Checkpoint Gene Dysregulation in Established Osteoarthritis: Integrated Transcriptomic Analysis and In Vitro Evaluation of CDK6 and WEE1 · Biomedicines · 26 Aug 2026

CDK6 →

1. Osteoarthritis is associated with CDKN1A in silico (AUC 0.931).

   “CDKN1A, CDK6, and WEE1 were reduced in OA-associated meniscal samples in GSE98918; within-dataset ROC analyses yielded AUCs of 0.931, 0.882, and 0.792, respectively.”

   In silicomeniscus

   Senescence-Associated Checkpoint Gene Dysregulation in Established Osteoarthritis: Integrated Transcriptomic Analysis and In Vitro Evaluation of CDK6 and WEE1 · Biomedicines · 26 Aug 2026

CDKN1A →